摘要
目的:探讨血清学指标结合彩色多普勒超声对孕早期唐氏综合征筛查的临床效果。方法:回顾性分析2019年1月-2020年12月期间来我院就诊的62名11-13+周孕产妇的临床资料,采用时间分辨荧光免疫分析法检测孕妇血清中妊娠相关血浆蛋白A(PAPP-A)以及游离β-人绒毛膜促性腺激素(Fβ-HCG),联合超声测定胎儿颈部透明层厚度(NT)。结果:2例通过引产证实存在唐氏综合征。血清学检查检出率为50.00%,彩色多普勒超声检出率为50.00%,联合检查检出率为100.00%,联合检查显著优于血清学、彩色多普勒超声单独检测(P<0.05)。2例确诊为唐氏综合征胎儿的孕妇年龄大于34岁,孕周在12-13周,仅有1例血清学检查高于唐氏综合征高风险截断值为1:250,彩色多普勒超声检查提示NT>3mm。唐氏综合征筛查风险高低与妊娠结局相关,高风险组妊娠异常率显著高于低风险组,且数据差异有统计学意义(P<0.05)。结论:血清学指标结合彩色多普勒超声对孕早期唐氏综合征筛查的检出率高,对妊娠结局有一定指导意义,值得在临床上推广。
Objective:To explore the clinical effect of serum markers combined with color Doppler ultrasound in screening Down’s syndrome in early pregnancy.Methods:the clinical data of 6211-13+week pregnant women from January 2019 to December 2020 in our hospital were retrospectively analyzed.The serum PAPP-A and f β-hCG were detected by time-resolved fluoroimmunoassay,and the fetal neck hyaline membrane thickness(NT)was measured by ultrasound.Results:2 cases were induced by labor,and 2 cases were confirmed to have Down syndrome.The detection rates of serological examination,color Doppler ultrasound and combined examination were 50.00%,50.00%and 100.00%,respectively.Combined examination was significantly better than serological examination and color Doppler ultrasound alone(P<0.05).Two pregnant women who were diagnosed as Down syndrome fetuses were older than 34 years old and the gestational age was 12-13 weeks.Only one serological examination was higher than Down syndrome with a high risk cutoff value of 1:250.Color Doppler ultrasound examination showed NT>3mm.The screening risk of Down’s syndrome may be related to pregnancy outcome.The abnormal pregnancy rate in high-risk group is significantly higher than that in low-risk group,and the data difference is statistically significant(P<0.05).Conclusion:the detection rate of serum indicators combined with color Doppler ultrasound in screening Down’s syndrome in early pregnancy is high,which has certain guiding significance for pregnant women’s pregnancy outcome,and is worthy of clinical promotion.
作者
林旭涛
林旭升
张雄如
LIN Xu-tao;LIN Xu-sheng;ZHANG Xiong-ru(Department of Ultrasound,Chaoyang District Dafeng Hospital of Shantou,Guangdong 515154,China;Department of General Surgery,Chaoyang District Dafeng Hospital of Shantou,Guangdong 515154,China;Department of Internal Medicine,Shantou Central Hospital,Guangdong 515000,China)
出处
《影像技术》
CAS
2021年第5期60-64,共5页
Image Technology
