摘要
目的探索非小细胞肺癌(NSCLC)不同分期的中医证候、证素分布规律。方法计算机检索中国知网(CNKI)、中国生物医学文献数据(CBM)、维普中文期刊数据库、万方数据库中NSCLC证候或证素相关文献,检索时间从各数据库建库至2019年7月31日。将NSCLC按照TNM(tumor node metastasis classification)分期分为Ⅰ、Ⅱ、Ⅲ、Ⅳ期,提取纳入文献各期中证候、证素信息,建立数据库;采用描述性统计,分析各期的证候、证素分布规律。结果共纳入32篇合格文献,累计报道病例5286例。将频率≥3%的10个证型作为常见证候,包括气阴两虚证、肺气虚证、肺脾气虚证、痰湿阻肺证、痰热壅肺证、脾虚痰湿证、阴虚内热证、气滞血瘀证、瘀阻肺络证、痰瘀互结证。将频率≥3%的证素作为常见证素,常见病位证素为肺、脾;常见病性证素为气虚、痰、阴虚、湿、热、血瘀、气滞。结论NSCLC发病以正虚为基础,病位在肺,与脾密切相关。Ⅰ期证候以肺脾气虚证、气阴两虚证、痰湿阻肺证为主,病性证素以气虚、阴虚、痰为主;Ⅱ期证候以肺气虚证、肺脾气虚证、痰湿阻肺证为主,病性证素以气虚、痰、热为主;Ⅲ期证候以气阴两虚证、肺气虚证、痰湿阻肺证为主,病性证素以气虚、痰、阴虚为主;Ⅳ期证候以气阴两虚证、肺气虚证、痰湿阻肺证为主,病性证素以气虚、痰、阴虚为主。
Objective To explore the characteristics of traditional Chinese medicine(TCM)syndromes and syndrome elements of non-small cell lung cancer(NSCLC)at different stages.Methods Electronic databases including CNKI,CBM,VIP and Wanfang Databases were searched for literature on syndromes and syndrome elements of NSCLC from the inception dates to July 31st,2019.The papers were extracted according to the tumor node metastasis classification(TNM)staging system which classified NSCLC into stageⅠ,Ⅱ,Ⅲ,and Ⅳ,and data on TCM syndromes and syndrome elements were collected to establish a database;descriptive statistics were used to analyze the distribution characteristics of the syndromes and syndrome elements of each stage.ResultsA total of 32 articles were included involving 5,286 cases.There were ten common TCM syndromes with frequency ≥3%,which were deficiency of both qi and yin syndrome,lung qi deficiency syndrome,lung-spleen qi deficiency syndrome,phlegm-damp obstructing the lung syndrome,phlegm-heat obstructing the lung syndrome,spleen deficiency and phlegm-damp syndrome,yin deficiency with internal heat syndrome,qi stagnation and blood stasis syndrome,stasis obstructing the lung collaterals syndrome,and binding of phlegm and stasis syndrome.Taking frequency ≥3% as a criteria for screening the common syndrome elements,lung and spleen were the commonly seen location of diseases,the common elements related to nature of disease were qi deficiency,phlegm,yin deficiency,damp,heat,blood stasis and qi stagnation.ConclusionHealthy qi deficiency is the basis of NSCLC;the location of the disease is in the lung,and the spleen is closely related.For stage I NSCLC,lung-spleen qi deficiency syndrome,deficiency of both qi and yin syndrome,and phlegm-damp obstructing the lung syndrome were commonly seen,as well as the disease nature-related elements including qi deficiency,yin deficiency and phlegm;the common syndromes of stage Ⅱ NSCLC were lung qi deficiency syndrome,lung-spleen qi deficiency syndrome,and phlegm-damp obstructing the lung syndrome,and the main nature of disease were qi deficiency,phlegm and heat;stage Ⅲ NSCLC was characterized by deficiency of both qi and yin syndrome,lung-qi deficiency syndrome,and phlegm-damp obstructing the lung syndrome,and qi deficiency,phlegm and yin deficiency were commonly seen;regarding the stage Ⅳ NSCLC,deficiency of both qi and yin syndrome,lung-qi deficiency syndrome and phlegmdamp obstructing the lung syndrome were the common TCM syndromes,and qi deficiency,phlegm and yin deficiency were the common disease nature-related elements.
作者
刘文瑞
冯贞贞
李建生
LIU Wenrui;FENG Zhenzhen;LI Jiansheng(Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P.R.China,Henan University of Chinese Medicine,Zhengzhou,450046)
出处
《中医杂志》
CSCD
北大核心
2021年第18期1635-1639,共5页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81830116)
国家中医药传承与创新“百千万”人才工程(岐黄工程)(国中医药人教函[2018]284号)
国家“万人计划”百千万工程领军人才项目(W02060076)。
关键词
非小细胞肺癌
证候
证素
文献研究
TNM分期
non-small cell lung cancer
syndromes
syndrome elements
literature research
TNM staging
