摘要
Biomedical implants have revolutionised medicine,while they also increase the risk of implant-associatedinfection which is one of the most frequent and severe complications accpmpanied by the application of biomaterials.Since the widespread usage of antibiotics drives the emergence of multidrug-resistant strains,the orthopaedic implantinfections are usually hard to treat due to the antibiotic resistance,tolerance and/or persistence of pathogens.Giventhe growing impact of multidrug resistance,an urgent need has been triggered to develop new types of antimicrobialstrategy other than using antibiotics.In this review,the authors highlight the recent progress on antimicrobialbiomaterials with non-antibiotic strategies including chemical strategy,physical strategy,and synergetic strategy.The antimicrobial mechanisms of many kinds of non-antibiotic antimicrobial biomaterials are still not fully understood.Researchers gradually found that welcoming microbial cellular adhesion to a lethal surface was a more effectivesolution than targeting microbial cellular repulsion when designing antimicrobial surfaces.Moreover,there is a populartendency to make the antimicrobial biomaterials not only kill pathogenic microbes but also facilitate the adhesion andgrowth of the healthy cell,which means that the next generation biomaterials should possess dual functions ofpreventing microbial infection together with promoting tissue regeneration simultaneously for biomedical applications.
基金
the Natural ScienceFoundation of Tianjin(General Program,No.18ICYBJC19500)
the Independent Innovation Fund of Tianjin University(2019XZS-0014).
