摘要
目的探讨甲胎蛋白(AFP)、甲胎蛋白异质体(AFP-L3)与肿瘤坏死因子α(TNF-α)检测在原发性肝癌诊断中的应用价值。方法选取2019年1月至12月在衡阳市中心医院接受治疗的50例原发性肝癌患者作为研究组,并选取同时期来衡阳市中心医院体检的50例健康者为对照组。两组均进行AFP、AFP-L3、TNF-α检测,比较并分析两组的AFP、AFP-L3与TNF-α检测结果,研究不同病理分期患者的检测结果以及联合检测的诊断效能。结果研究组的AFP、AFP-L3与TNF-α水平高于对照组,差异有统计学意义(P<0.05)。肿瘤分期为Ⅲ-Ⅳ期患者的AFP、AFP-L3与TNF-α水平高于肿瘤分期为Ⅰ-Ⅱ期患者,差异有统计学意义(P<0.05);中分化组、高分化组患者的AFP、AFP-L3与TNF-α水平低于低分化组,差异有统计学意义(P<0.05);AFP、AFP-L3与TNF-α指标联合检测的敏感度高于单独检测,差异有统计学意义(P<0.05)。结论对原发性肝癌患者进行AFP、AFP-L3以及TNF-α联合检测,能够对患者病情严重程度进行反映,检测的敏感度较高,利于临床应用及推广。
Objective To explore the application value ofα-fetoprotein(AFP),α-fetoprotein heterogenes(AFP-L3)and tumor necrosis factor-α(TNF-α)detection in the diagnosis of primary liver cancer.Methods Fifty patients with primary liver cancer who were treated in Hengyang Central Hospital from January to December 2019 were selected as the research group,and 50 healthy people who came to Hengyang Central Hospital for physical examination during the same period were selected as the control group.The two groups of personnel were tested for AFP,AFP-L3 and TNF-α.The two groups were compared and analyzed for AFP,AFP-L3 and TNF-αtest results,test results of patients with different pathological stages in the study group and the diagnostic power of the combined test.Results The levels of AFP,AFP-L3 and TNF-αof the study group were higher than those of the control group,the differences were statistically significant(P<0.05).The levels of AFP,AFP-L3 and TNF-αin patients with tumor stage ofⅢ-Ⅳwere higher than those in patients with tumor stage ofⅠ-Ⅱ,and the differences were statistically significant(P<0.05).The levels of AFP,AFP-L3 and TNF-αof patients in the moderately differentiated group and the well-differentiated group were lower than those of the poorly differentiated group,and the differences were statistically significant(P<0.05).The sensitivity of the combined detection of AFP,AFP-L3 and TNF-αindicators were higher than those of independent detection,and the differences were statistically significant(P<0.05).Conclusion The combined detection of AFP,AFP-L3 and TNF-αin patients with primary liver cancer can reflect the severity of the patient′s condition,and the detection is highly sensitive,which is beneficial to clinical application and promotion.
作者
张丹霞
张永虎
桂若虎
王晓洋
伍友兴
ZHANG Dan-xia;ZHANG Yong-hu;GUI Ruo-hu;WANG Xiao-yang;WU You-xing(Department of Gastroenterology,Hengyang Central Hospital,Hu′nan Province,Hengyang 421000,China;Department of Emergency,the Second Affiliated Hospital of Nanhua University,Hu′nan Province,Hengyang 421000,China;不详)
出处
《中国当代医药》
CAS
2021年第26期223-225,229,共4页
China Modern Medicine
关键词
原发性肝癌
甲胎蛋白
甲胎蛋白异质体
肿瘤坏死因子Α
诊断效能
Primary liver cancer
α-fetoprotein
α-fetoproteine heterogeneity
Tumor necrosis factor-α
Diagnostic power
