摘要
为实现组织工程的各种三维构建,需要寻找一种合适的生物墨水来进行活体组织的打印。甲基丙烯酸酐化明胶(GelMA)已被用于各种组织工程的三维构建,其力学性能的设计需要在满足生物打印和细胞生长的要求中寻求平衡。为了改善GelMA水凝胶力学性能和物理性质,使其满足不同组织器官的机械性能,采用丙烯酰化的方法将甲基丙烯酸酐(MA)与明胶反应,在明胶分子链上引入双键结构,并通过制备GelMA水凝胶、GelMA-ChelMA(甲基丙烯酸酐化壳聚糖)水凝胶、GelMA-PEG(200)DA水凝胶,进行力学和物理性能分析。结果表明,GelMA中加入ChelMA、PEG(200)DA可以增大弹性模量,其物理性质受到一定程度影响。
In order to realize various 3D constructions in tissue engineering,suitable bio-ink methods need to be found for printing living tissue.GelMA has been used in the three-dimensional construction in various tissue engineering.To make the good use of GELMA,it is necessary to find a balance between the requirement for meeting the mechanical propert of bio-printing and cell growth.The purpose of this study is to improve the mechanical properties and physical properties of GelMA hydrogel,so that it can meet the mechanical properties of different tissues and organs.Acrylate anhydride(MA)was reacted with gelatin by acrylization,and double bond structure was introduced into gelatin molecular chain.GelMA hydrogel,GelMA-ChelMA(methyl acrylate anhydride chitosan)hydrogel,and GelMA-PEG(200)DA hydrogel were prepared for mechanical and physical property analyses.The results show that ChelMA and PEG(200)DA could increase the elastic modulus of GelMA,and the physical properties were affected to a certain extent.
作者
李媛媛
温瑜
李俊
李鹏飞
白天宇
张庆涛
王颖
LI Yuanyuan;WEN Yu;LI Jun;LI Pengfei;BAI Tianyu;ZHANG Qingtao;WANG Ying(College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China)
出处
《太原理工大学学报》
CAS
北大核心
2021年第5期842-848,共7页
Journal of Taiyuan University of Technology
基金
国家自然科学基金青年资助项目(11602159)
山西省大创资助项目(2018083)。
