摘要
目的探讨冷沉淀在肝硬化门脉高压症(PHT)患者围术期的应用效果。方法选取2018年8月—2019年12月江西省宜春市人民医院北院收治的86例肝硬化PHT患者作为研究对象,按照随机抽签法分为对照组(43例)和观察组(43例),对照组围术期给予灭活冰冻血浆、去白悬浮红细胞等成分血,观察组围术期给予冷沉淀,比较两组凝血功能、医疗费用、24 h去白细胞悬浮红细胞用量、住院时间。结果观察组输注后24 h血浆凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、D二聚体(D-D)水平均低于对照组,纤维蛋白原(FBG)水平高于对照组,差异有统计学意义(P<0.05);观察组医疗费用、24 h去白细胞悬浮红细胞用量少于对照组,住院时间短于对照组,差异有统计学意义(P<0.05)。结论在肝硬化PHT患者围术期应用冷沉淀可改善患者凝血功能,减少医疗费用,缩短住院时间,值得推广。
Objective To investigate the effect of cryoprecipitation in perioperative period of patients with portal hypertension(PHT)of liver cirrhosis.Methods A total of 86 patients with cirrhosis and PHT who were admitted to the Yichun People′s Hospital in Jiangxi Province from August 2018 to December 2019 were selected as the research objects.They were divided into the control group(43 cases)and the observation group(43 cases)according to the random lottery method.The control group was given blood components such as inactivated frozen plasma and leukocyte-free suspended red blood cells during the perioperative period,and the observation group was given cryoprecipitate during the perioperative period.The coagulation function,medical expenses,amount of leukocyte-removed suspended red blood cell in 24 hours,and hospital stay were compared between the two groups.Results The postoperative plasma prothrombin time(PT)24 hours after infusion,activated partial thromboplastin time(APTT),thrombin time(TT),and D-Dimer(D-Dimer,D-D)level were lower than the control group,and the fibrinogen(FBG)level was higher than that of the control group,the differences were statistically significant(P<0.05).The medical expenses and the amount of leukocyte-removed and suspended red blood cells in 24 hours of the observation group were less than those of the control group,the hospital stay was shorter than the control group,the differences were statistically significant(P<0.05).Conclusion The application of cryoprecipitation in cirrhosis patients with portal hypertension during perioperative period can improve the coagulation function of patients,reduce medical costs and shorten the length of hospital stay,which is worthy of promoting.
作者
曾勇
朱楷
刘煌
ZENG Yong;ZHU Kai;LIU Huang(First Aid Center for Trauma,Yichun People′s Hospital,Jiangxi Province,Yichun 336000,China)
出处
《中国当代医药》
CAS
2021年第24期55-57,61,共4页
China Modern Medicine
基金
江西省宜春市科技计划项目(JXYC2019KSA004)。
关键词
冷沉淀
肝硬化
门脉高压症
围术期
凝血功能
Cryoprecipitation
Cirrhosis
Portal hypertension
Perioperative period
Blood coagulation function
