摘要
目的探讨乳腺癌家族史(family history,FH)与绝经后乳腺癌临床病理因素及生存预后的关系。方法根据有无家族史,将240例行手术治疗的绝经后乳腺癌患者分成FH(+)组和FH(-)组,分析2组临床病理特征及预后情况。结果240例患者中FH(+)者25例(10.4%)。与FH(-)组比较,FH(+)组平均发病年龄低,ER/PR阴性率、Her-2阳性率较高,差异均有统计学意义(P<0.05)。Kaplain-Meier曲线(log-rank检验)结果显示,乳腺癌家族史对绝经后乳腺癌患者OS的影响有统计学意义(χ^(2)=15.772,P<0.001)。多因素Cox回归分析结果显示,Her-2阳性、FH是乳腺癌患者生存预后的危险因素(P<0.05),ER阳性是其保护性因素(P<0.05)。结论绝经后乳腺癌家族史阳性者发病年龄更轻,Her-2阳性、乳腺癌家族史是乳腺癌患者生存预后的危险因素,ER阳性是乳腺癌患者生存预后的保护因素。
Objective To explore the relationship between family history(FH)of breast cancer and clinicopathological factors forpostmenopausal breast cancer and its influence on prognosis.Methods A total of 240 postmenopausal breast cancer patients who underwent surgical treatment for breast cancer were divided into FH(+)group and FH(-)group according to the family history,and the clinicopathological characteristics and prognosis between two groups were compared.Results Of the 240 postmenopausal breast cancer patients,25(10.4%)had a positive family history.The average age of onset in the FH(+)group was lower,the negative rate of ER/PR,and the positive rate of Her-2 were higher than those in the FH(-)group,and the differences were statistically significant(P<0.05).Kaplain-Meier survival analysis and log-rank test showed that the family history of breast cancer had a statistically significant effect on the OS of postmenopausal breast cancer patients(χ^(2)=15.772,P<0.001).Multivariate Cox risk regression analysis showed that the positive expression of Her-2 and positive family history were risk factors for the prognosis in postmenopausal breast cancer patients,while the positive ER was a protective factor.Conclusions A positive family history of post-menopausal breast cancer is associated with a younger age of onset.The positive expression of Her-2 and a family history of breast cancer are risk factors for the survival prognosis of breast cancer patients,while the positive of ER is a protective factor for breast cancer.
作者
王昭君
陈美华
马海广
张祥建
许践刚
WANG Zhaojun;CHEN Meihua;MA Haiguang;ZHANG Xiangjian;XU Jiangang(Department of Oncological Surgery,Wenzhou Central Hospital,Wenzhou 325000,China)
出处
《健康研究》
CAS
2021年第4期423-427,共5页
Health Research
基金
温州市科技局科技计划项目(Y20190754)。
关键词
乳腺癌
绝经后
家族史
预后
breast cancer
postmenopausal
family history
prognosis
