摘要
目的探讨国产LY-121泪膜干涉成像仪对泪膜分级诊断的可靠性、可重复性。方法收集2018年3月至9月首都医科大学附属北京同仁医院眼科门诊有干眼症状的22例(43眼)患者,应用国产LY-121泪膜干涉成像仪拍摄泪膜图像,参考日本DR-I泪膜分级标准进行诊断分级;由一名眼科医师在不同时段对同一批图像进行分级诊断,并由另一名眼科医师对同一批图像进行分级诊断,采用加权Kappa系数评价医师内部和医师之间的一致性,以及国产LY-121泪膜干涉成像仪和国外设备的一致性。结果LY-121泪膜干涉成像仪泪膜成像清晰,同一名医师两次的1~4级诊断眼数分别为:6、17、12、8和6、18、14、5,两者的一致比例达88.4%,差异无统计学意义(P>0.05),Kappa值为0.818(95%CI:0.707,0.929)。两名医师的1~4级诊断结果比较:医生1的分级结果为6、17、12和8眼,医生2则分为7、21、10和5眼,两者一致的比例为76.8%,差异无统计学意义(P>0.05),Kappa值为0.781(95%CI:0.775,0.787)。两种仪器比较:国产LY-121泪膜干涉成像仪的诊断结果分别为6、17、12和8眼,OCULUS眼表综合分析仪的诊断结果分别为6、15、12和8眼,两者比较,差异无统计学意义(P>0.05),Kappa值为0.862(95%CI:0.803,0.921)。结论国产LY-121泪膜干涉成像仪诊断干眼症的一致性和重复性较好,性能不劣于进口成熟设备。
Objective To investigate the reliability and repeatability of domestic LY-121 tear film interference imager for tear film grading diagnosis.Methods Twenty-two patients(43 eyes)with dry eye symptoms in the ophthalmic clinic of Beijing Tongren Hospital,Capital Medical University from March to September 2018 were collected.The domestic LY-121 tear film interference imager was used to take tear film images,and the diagnostic grades were performed according to the Japanese DR-I tear film grading standard.One ophthalmologist graded the same batch of images at different time periods,and another ophthalmologist graded the same batch of images.The weighted Kappa coefficient was used to evaluate the consistency among physicians and within physicians,as well as the consistency between domestic LY-121 tear film interference imager and foreign equipment.Results LY-121 tear film interference imager had clear tear film imaging.The number of eyes diagnosed at grade 1 to 4 by the same physician twice was 6,17,12,8 and 6,18,14,5,respectively.The consistent proportion between the two was 88.4%,with no statistical significance(P>0.05).Kappa value was 0.818(95%CI:0.707,0.929).Comparison of grade 1 to 4 diagnosis results between the two physicians:6,17,12,and 8 eyes were graded by doctor 1 and 7,21,10 and 5 eyes were graded by doctor 2.The consistent proportion between the two was 76.8%,with no statistical significance(P>0.05).Kappa value was 0.781(95%CI:0.775,0.787).Comparison of the two instruments:the diagnostic results of the domestic LY-121 tear film interference imager were 6,17,12 and 8 eyes respectively,and the diagnostic results of OCULUS eye-surface comprehensive analyzer were 6,15,12 and 8 eyes respectively,and there was no statistical significance between them(P>0.05).Kappa value was 0.862(95%CI:0.803,0.921).Conclusion The consistency and repeatability of domestic LY-121 tear film interference imager in the diagnosis of dry eye disease are good,and the performance is not inferior to that of imported mature equipment.
作者
陈长喜
张阳
张景尚
安莹
邓世靖
万修华
曹凯
王进达
CHEN Changxi;ZHANG Yang;ZHANG Jingshang;AN Ying;DENG Shijing;WAN Xiuhua;CAO Kai;WANG Jinda(Beijing Tongren Hospital,Capital Medical University Beijing Tongren Eye CenterBeijing Institute of Ophthalmology Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing 100005,China)
出处
《中国医药导报》
2021年第24期60-63,共4页
China Medical Herald
基金
首都卫生发展科研专项(首发2011-1016-05)。
关键词
干眼症
诊断
泪膜干涉成像仪
一致性
可重复性
Dry eyes
Diagnosis
Tear film interference imager
Consistency
Repeatability
