摘要
目的:探讨158例住院患者标本中耐碳青霉烯类肠杆菌科细菌的临床分布及耐药情况。方法:选取2018年3月—2020年3月住院患者158例资料,根据全国临床检验操作规程进行标本的采集及细菌培养,统计病原菌的类型及科室分布情况;采用BD Phoenix 100系统,以全自动生化分析仪检测病原菌耐药率并进行分析。结果:158例住院患者采集标本158份,共检出耐碳青霉烯类肠杆菌科细菌185株,构成比排在前三位的为肺炎克雷伯菌、阴沟肠杆菌及大肠埃希菌,分别占70.89%、13.29%和8.23%;耐碳青霉烯类肠杆菌科细菌科室分布较广,构成比排在前三位的分别为重症监护病房(ICU)、脑病科及呼吸内科,分别占50.00%、19.62%和7.59%;对主要耐碳青霉烯类肠杆菌科进行耐药率分析显示,肺炎克雷伯菌对其耐药率排名前三位的分别为美罗培南、氨苄西林及阿莫西林-克拉维酸钾,分别占100.00%、99.11%、97.32%;阴沟肠杆菌对其耐药率最高的为氨苄西林、头孢唑林、阿莫西林-克拉维酸钾及美罗培南,均为100.00%。结论:耐碳青霉烯类肠杆菌科细菌的耐药情况较为严重,且主要分布在ICU;医院不同部门应加强联动干预及防控,合理使用抗菌药物,以降低该类菌株的感染率。
Objective:To analyze the clinical distribution and drug resistance of carbapenem-resistant Enterobacteriaceae bacteria in 158 inpatients’specimens.Methods:A total of 158 inpatients from March 2018 to March 2020 were selected as the subjects.Samples were collected and bacteria were cultured according to the national clinical laboratory operating procedures,then the types and department distribution of pathogenic bacteria were recorded.The drug resistance rate of pathogenic bacteria was analyzed with automatic biochemical analyzer.Results:A total of 185 strains of carbapenem-resistant enterobacteriaceae bacteria were detected in 158 inpatients’samples.Klebsiella pneumoniae,Enterobacter cloacae and Escherichia coli were the top three pathogenic bacteria,accounting for 70.89%,13.29%and8.23%respectively.The department distribution of carbapenem-resistant enterobacteriaceae bacterial was wide,and the top three were intensive care unit(ICU),encephalopathy department and respiratory department,accounting for50.00%,19.62%and 7.59%.The drug resistance rate analysis of the main carbapenem-resistant enterobacteriaceae showed that the top three resistance rate drugs of Klebsiella pneumoniae were meropenem,ampicillin and amoxicillinclavulanate potassium(accounting for 100.00%,99.11%and 97.32%).The top resistance rate drugs of Enterobacter cloacae were ampicillin,cefazolin,amoxicillin-clavulanate potassium and meropenem,all of which were 100.00%.Conclusions:Drug resistance of carbapenem-resistant Enterobacteriaceae bacteria is serious,and its’main distributed deparement is ICU.Different departments of the hospital should strengthen joint intervention and control,thus using antibacterial agents rationally and reducing the infection rate of such bacteria.
作者
娄宏
Lou Hong(Laboratory Department of Luohe second people's Hospital,Luohe Henan 462000)
出处
《抗感染药学》
2021年第5期655-659,共5页
Anti-infection Pharmacy
