摘要
目的研究不同年龄患者冻融周期胚胎移植时子宫内膜厚度、形态及血流类型对临床结局的影响。方法回顾性分析接受冻胚移植的患者临床资料,共纳入853个周期,以患者年龄分段,采用经阴道彩色多普勒超声技术评价冻胚周期子宫内膜转化日内膜的厚度、形态以及血流分型情况,比较其与患者胚胎种植率及妊娠率之间的关系,并通过ROC曲线分析不同指标对临床妊娠结局的预测价值。结果随着年龄的增长,患者胚胎种植率及妊娠率呈下降趋势。子宫内膜厚度在8~14 mm时妊娠率最高,<8 mm次之,而≥14 mm妊娠率最低,但不同年龄段患者趋势不同。各年龄段患者C型组均无患者妊娠,A型组子宫内膜的妊娠率及种植率与B型组无差异。随着子宫内膜血流丰富程度的增加,患者妊娠率逐渐升高。II型组种植率最高,其次为III型组,I型组种植率最低,但在各年龄段中三组患者妊娠率及种植率无统计学差异。ROC曲线提示内膜血流分型可作为预测临床妊娠结局的指标。结论冻融周期胚胎移植的妊娠率和种植率随着年龄增长而下降。子宫内膜转化日的内膜厚度、形态及血流类型可影响不同年龄段患者冻胚移植的种植率及妊娠率,其中内膜血流分型可预测冻胚移植患者的临床妊娠结局。
Objective To study the effects of endometrial thickness,patterns and blood flow types on the clinical outcome of frozen embryo transplantation in patients of different ages.Methods The clinical data of patients who received frozen embryo transplantation were retrospectively analyzed and 853 cycles were included.The patients were divided into different age groups.The endometrium thickness,patterns and blood flow types were evaluated by vaginal color Doppler ultrasound.The influence of endometrium thickness,patterns and blood flow types on pregnancy outcome in patients of different ages was studied.The predictive value of endometrial thickness,patterns and blood flow types on clinical pregnancy outcome was analyzed by using ROC curve.Results With the increase of age,the embryo implantation rate and pregnancy rate of patients showed a downward trend.The pregnancy rate is the highest when the endometrial thickness is 8-14mm,followed by<8 mm,and the pregnancy rate≥14 mm is the lowest,but the trends are different for patients of different ages.There was no pregnancy in the type C group of patients of all ages,and the pregnancy rate and implantation rate of the endometrium in the type A group were not different from those in the type B group.With the increase in the abundance of endometrial blood flow,the pregnancy rate of patients gradually increased.The implantation rate of type II group was the highest,followed by type III group,and the implantation rate of type I group was the lowest.However,there was no statistical difference in pregnancy rate and implantation rate among the three groups of data in each age group.The ROC curve suggests that the endometrial blood flow types can be used as indicators to predict clinical pregnancy outcome.Conclusion The clinical pregnancy rate and implantation rate of embryo transfer during freeze-thaw cycles decrease with age.Endometrial thickness,patterns and blood flow types can affect the implantation rate and clinical pregnancy rate of embryo transfer.Endometrial blood flow types on the day of endometrial transformation can predict the clinical pregnancy outcome of embryo transfer patients during the freeze-thaw cycle.
作者
劳凯雪
刁兴华
李晴晴
邱玉晨
梅娟娟
王雁林
LAO Kaixue;DIAO Xinghua;LI Qingqing;QIU Yuchen;MEI Juanjuan;WANG Yanlin(Reproductive Medicine Center,Binzhou Medical University Hospital,Binzhou 256603,Shandong,P.R.China;Obstetrics and Gynecology Department,Binzhou Medical University Hospital,Binzhou 256603,Shandong,P.R.China)
出处
《滨州医学院学报》
2021年第3期173-177,共5页
Journal of Binzhou Medical University
基金
山东省医药卫生科技发展计划(2017WS364)。
关键词
子宫内膜容受性
冻胚移植
临床妊娠
endometrial receptivity
frozen embryo transfer
clinical pregnancy
