摘要
目的:观察单硝酸异山梨酯缓释片联合灯盏生脉胶囊对老年冠心病心绞痛患者血脂、心功能及血清C反应蛋白(CRP)、白介素-6(IL-6)水平的影响。方法:选择2018年3月至2020年7月期间我院收治的92例老年冠心病心绞痛患者,采用随机数字表将患者分为两组,分别为对照组46例和研究组46例。对照组给予单硝酸异山梨酯缓释片治疗,研究组则给予灯盏生脉胶囊联合单硝酸异山梨酯缓释片治疗,疗程均为3个月。对比两组临床症状、心电图变化、心功能、血脂及血清IL-6、CRP水平,记录两组不良反应发生情况。结果:研究组的临床总有效率高于对照组(P<0.05);研究组的心电图总改善率高于对照组(P<0.05)。治疗3个月后,两组血清低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)、IL-6、CRP水平较治疗前降低,且研究组低于对照组(P<0.05),高密度脂蛋白胆固醇(HDL-C)水平较治疗前升高,且研究组高于对照组(P<0.05)。治疗3个月后,两组左心室收缩末期内径(LVESD)较治疗前降低,且研究组低于对照组(P<0.05),左心室射血分数(LVEF)、心输出量(CO)较治疗前升高,且研究组高于对照组(P<0.05)。两组不良反应发生率组间对比无差异(P>0.05)。治疗3个月后,研究组硝酸甘油用量少于对照组,心绞痛发作频率、心绞痛持续时间、心绞痛缓解时间短于对照组(P<0.05)。结论:老年冠心病心绞痛患者在单硝酸异山梨酯缓释片治疗的基础上联合灯盏生脉胶囊治疗,效果显著,可有效改善其心功能、血脂,调节炎症因子水平,安全性较好。
Objective:To observe the effect of isosorbide mononitrate combined with Dengzhan Shengmai Capsule on blood lipid,cardiac function and serum C-reactive protein(CRP)and interleukin-6(IL-6)levels in elderly patients with coronary heart disease and angina pectoris.Methods:92 elderly patients with coronary heart disease and angina pectoris in our hospital from March 2018 to July2020 were selected,and they were divided into two groups by drawing lots,46 cases in the control group and 46 cases in the study group.The control group was treated with isosorbide mononitrate,while the study group was treated with Dengzhan Shengmai capsule combined with isosorbide mononitrate.The course of treatment was 3 months.The clinical symptoms,electrocardiographic effect,cardiac function,blood lipid,serum IL-6 and CRP levels were compared between the two groups,and the incidence of adverse reactions was recorded.Results:The total effective rate of the study group was higher than that of the control group(P<0.05).The total effective rate of electrocardiographic in the study group was higher than that in the control group(P<0.05).After 3 months of treatment,the levels of serum low density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC),IL-6 and CRP in the two groups were lower than those before treatment,and the level of high density lipoprotein cholesterol(HDL-C)in the study group was higher than that in the control group(P<0.05).After 3 months of treatment,the left ventricular end systolic diameter(LVESD)of the two groups was lower than that before treatment,and the study group was lower than that of the control group(P<0.05),the left ventricular ejection fraction(LVEF)and cardiac output(CO)were higher than those before treatment,and the study group was higher than that of the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).After 3 months of treatment,the dosage of nitroglycerin in the study group was less than that in the control group,the frequency of angina pectoris attack,the duration of angina pectoris and the remission time of angina pectoris in the study group were shorter than those in the control group(P<0.05).Conclusion:The combination of isosorbide mononitrate sustained-release tablets and Dengzhan Shengmai capsule in the treatment of elderly patients with coronary heart disease and angina pectoris has significant effect,which can effectively improve their cardiac function,blood lipid,regulate the level of inflammatory factors,and has good safety.
作者
郭红玲
欧阳艳红
王圣
黄咏东
苏健玲
GUO Hong-ling;OUYANG Yan-hong;WANG Sheng;HUANG Yong-dong;SU Jian-lin(Special Diagnosis Department of Health Care Center,Hainan Provincial People's Hospital,Haikou,Hainan,570311,China;Department of Emergency Medicine,Hainan Provincial People's Hospital,Haikou,Hainan,570311,China;Department of Internal Medicine-Cardiovascular,Hainan Provincial People's Hospital,Haikou,Hainan,570311,China;Department of Gastroenterology,Hainan Provincial People's Hospital,Haikou,Hainan,570311,China;Department of Rehabilitation Medicine,Hainan West Central Hospital,Danzhou,Hainan,571700,China)
出处
《现代生物医学进展》
CAS
2021年第12期2373-2376,2339,共5页
Progress in Modern Biomedicine
基金
海南省自然科学基金项目(812150)。
关键词
老年
灯盏生脉胶囊
血脂
冠心病心绞痛
C反应蛋白
单硝酸异山梨酯缓释片
心功能
白介素-6
Elderly
Dengzhan Shengmai capsule
Blood lipid
Angina pectoris of coronary heart disease
C-reactive protein
Isosorbide mononitrate sustained release tablets
Cardiac function
Interleukin-6
