摘要
目的探讨复发性子痫前期的影响因素。方法回顾性分析2009年1月至2019年12月连续两次均在广州医科大学附属第三医院住院并终止妊娠,且前次妊娠为子痫前期患者共193例,根据再次妊娠是否并发子痫前期分为复发子痫前期组(56例)和对照组(未复发子痫前期,137例),采用卡方检验及二项分类logistic回归分析各因素与子痫前期复发之间的关系。结果(1)复发组中产次>2次(58.93%)较对照组(48.91%)增高,阴道分娩史(17.86%)较对照组(37.23%)降低,差异具有统计学意义(P均<0.05);复发组与对照组妊娠间隔1年(19.65%vs 3.65%)与2年(25.00%vs 29.93%)、3年(16.07%vs 26.28%)、≥4年(39.39%vs 40.15%)差异具有统计学意义(P<0.05)。(2)与妊娠间隔1年相比,妊娠间隔2年(OR=0.109,95%CI:0.028~0.423)、妊娠间隔3年(OR=0.056,95%CI:0.013~0.246),妊娠间隔≥4年(OR=0.080,95%CI:0.020~0.321)以及阴道分娩史(OR=0.199,95%CI:0.075~0.525)是子痫前期复发的保护因素,产次(OR=4.950,95%CI:1.848~13.262)是子痫前期复发的危险因素。结论妊娠间隔时间、阴道分娩史以及产次是影响子痫前期复发的主要因素。
Objective To investigate the risk factors of recurrent preeclampsia.Methods Retrospective analysis was performed on 193 patients from January 2009 to December 2019 in the Third Affiliated Hospital of Guangzhou Medical University.Women with consecutive deliveries within this time frame and complicated with preeclampsia in the first delivery were included in this cohort.According to whether the second pregnancy was complicated with preeclampsia,they were divided into the recurrent preeclampsia group(56 cases)and the non-recurrent preeclampsia group(137 cases).Data was analyzed with Chi-square test and binary logistic regression.Results(1)Compared with the non-recurrence group,the recurrence group has higher rate of more than 2 times of parities(58.93%vs 48.91%),shorter interval of pregnancy(19.65%、25.00%、16.07%、39.39%vs 3.65%、29.93%、26.28%、40.15%)and lower rate of vaginal delivery history(17.86%vs 37.23%),the difference was statistically significant(P<0.05).(2)Compared with one year interval of pregnancy,the 2 years interval of gestation(OR=0.109,95%CI:0.028-0.423),3 years(OR=0.056,95%CI:0.013-0.246),more than 4 years(OR=0.080,95%CI:0.020-0.321)and a history of vaginal delivery(OR=0.199,95%CI:0.075-0.525)were protective factors for recurrent preeclampsia.Parties more than 2 times(OR=4.950,95%CI:1.848-13.262)was a risk factor for recurrent preeclampsia.Conclusions Pregnancy interval,history of vaginal delivery and parity are the main factors affecting the recurrent preeclampsia.
作者
孙雯
王晓怡
余琳
林琳
王永
颜浩
徐允喆
古士锋
苏春宏
陈敦金
Sun Wen;Wang Xiaoyi;Yu Lin;Lin Lin;Wang Yong;Yan Hao;Xu Yunzhe;Gu Shifeng;Su Chunhong;Chen Dunjin(Department of Obstetrics and Gynecology,Third AffiliatedHospital of Guangzhou Medical University,Key Laboratory for Major Obstetric Diseases of Guangdong Province,Guangzhou Medical Center for Critical Pregnant Women,Guangzhou 510150,China)
出处
《中华产科急救电子杂志》
2021年第2期101-104,共4页
Chinese Journal of Obstetric Emergency（Electronic Edition）
基金
2018年广州医科大学附属第三医院博士启动项目(2018B10)。
关键词
子痫前期
复发
危险因素
Preeclampsia
Recurrent
Risk factors
