摘要
目的:探究吗啡与氢吗啡酮(HM)治疗难治性癌痛的效果。方法:86例难治性癌痛患者随机分为两组,观察组43例使用HM治疗,对照组43例使用吗啡治疗,两组均采用鞘内药物灌注系统(intrathecal drug delivery system,IDDS)给药。治疗10 d后,分析两组的镇痛及镇静效果、生活质量与不良反应。结果:观察组镇痛治疗的总有效率79.1%,高于对照组58.1%,差异有统计学意义(P<0.05);镇静效果优于对照组,生活质量KPS评分高于对照组(P<0.05);观察组不良反应发生率32.6%与对照组37.2%比较,差异无统计学意义(P>0.05)。结论:采用鞘内药物灌注系统给药,HM对难治性癌痛的镇痛效果优于吗啡。
Objective:To investigate the effects of morphine and hydromorphone(HM)on patients with refractory cancer pain.Methods:86 patients with refractory cancer pain were randomized into 2 groups.43 patients in the observation group were treated with HM,while another 43 patients in the control group were administered with morphine.Intrathecal drug infusion system was used in both groups.After 10 d of treatment,the analgesic and sedative effects,quality of life and adverse reactions of patients were compared between the two groups.Results:The total effective rate of analgesia treatment in the observation group was 79.1%,higher than 58.1%in the control group,and the difference was statistically significant(P<0.05);the sedative effect was better than that of the control group,and the KPS score of life quality was higher than that of the control group(P<0.05);and compared with 37.2%in the control group,the incidence of adverse reactions in the observation group was 32.6%,which was of no statistical significance between both groups(P>0.05).Conclusion:When using intrathecal drug infusion system,HM has better analgesic effect than morphine on patients with refractory cancer pain.
作者
郑留柱
ZHENG Liuzhu(Dept,of Pain Treatment,the Affiliated Zhengzhou Central Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《华夏医学》
CAS
2021年第2期127-130,共4页
Acta Medicinae Sinica
关键词
难治性癌痛
吗啡
氢吗啡酮
镇痛
refractory cancer pain
morphine
hydromorphone(HM)
analgesia
