摘要
缺血性脑卒中(cerebral ischemic stroke,CIS)可引发包括心、肝、脾、肺、肾在内的多个器官损伤,该类疾病是由多个病理环节组成,具有复杂的发病机制及高发病率、高致残率和高死亡率的特点,严重者可形成多器官功能障碍综合征(multiple organ dysfunction syndromes,MODS)。目前任何针对单一环节、单一靶点的治疗都不足以应对这一问题。研究发现中药可经多途径、多靶点,参与疾病的多个环节干预疾病。中药通过抗氧化作用、抑制炎症反应、调节能量代谢等对CIS引发的多器官损伤具有明显的保护作用。对中药及其有效成分对CIS后引起的多器官损伤及其相关机制进行了综述,以期更大程度地发挥祖国医学的治疗作用和治疗范围,为中药临床干预脑血管类合并多器官损伤类疾病提供科学依据和参考。
Cerebral ischemic stroke(CIS) can cause multiple organ injuries, which includes the heart, liver, spleen, lung, and kidney injuries. These diseases are composed of multiple pathological links, which have complex pathogenesis, high incidence rate, high disability rate, and high mortality rate. Severe cases can develop the multiple organ dysfunction syndromes(MODS). At present, any treatment aiming at single link and single target is not adequate to cure the disease. While it has been found that traditional Chinese medicine can intervene in many aspects of the diseases through multiple targets. Traditional Chinese medicine has obvious protective effect on MODS caused by CIS through antioxidant effect, inhibition of inflammatory reaction and regulation of energy metabolism. However, there are few related reviews. Therefore, the effects of traditional Chinese medicine and its active ingredients on multiple organ injuries after CIS are reviewed in this paper, so as to give full play to the therapeutic effect and treatment scope of traditional Chinese medicine, to provide scientific basis and reference for clinical intervention of traditional Chinese medicine in cerebrovascular diseases with multiple organ injuries.
作者
龙宇
张羽璐
万金艳
刘松雨
倪丽
李楠
杨明
LONG Yu;ZHANG Yu-lu;WAN Jin-yan;LIU Song-yu;NI Li;LI Nan;YANG Ming(College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;College of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第7期2106-2116,共11页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81673615)
国家大学生创新创业训练计划项目(S201910633028)
全国中药特色技术传承人才培训项目(T20194828003)
四川省人力资源和社会保障局资助项目(00809503)
四川省中医药管理局项目(2018QN009)
成都中医药大学杏林学者(QNXZ2018018)
成都中医药大学新冠病毒应急专项(XGZX2010)
江西中医药大学现代中药制剂教育部重点实验室开放基金资助项目(TCM-201908)。
关键词
中药
多靶点
缺血性脑卒中
多器官损伤
多器官功能障碍综合征
traditional Chinese medicine
multiple targets
cerebral ischemic stroke
multiple organs injury
multiple organ dysfunction syndromes
