摘要
前列腺癌是发生在前列腺的上皮性恶性肿瘤,是全球男性最常见的癌症,其死亡率仅次于肺癌,严重影响男性的健康生活。前列腺癌早期不易被发现,绝大多数患者确诊时已经处于晚期并发生转移,此时,不适用根治性手术进行治疗。晚期前列腺癌主要采取内分泌治疗,然而经过14~30个月的中位时间后,患者将发展为激素抵抗性前列腺癌并进入晚期。晚期激素抵抗性前列腺癌采用放、化疗治疗,然而放、化疗及内分泌治疗对于晚期前列腺癌的效果并不理想,同时会导致尿频、排尿困难、尿失禁、直肠出血、性欲减退、热潮红、阳痿等比较严重的副作用,并且产生多药耐药性。因此,寻找一种安全有效、低毒的抗肿瘤药物迫在眉睫。随着对多肽药理作用研究的深入,已证实多肽在抗疲劳、抗衰老、抗炎、抗菌和抗肿瘤等方面有重要的应用价值。抗肿瘤多肽具有特异性高、生物利用度高、稳定性好、毒性低、分子质量低、易于合成等特点,已经在抗肿瘤研究领域中受到了广泛的关注。药理实验表明,多肽主要通过诱导细胞凋亡、引起细胞周期阻滞、抑制血管生成以及调节免疫功能等多种途径发挥抗肿瘤作用。本文通过对多肽近年来相关文献的整理归纳,对其来源、抗前列腺癌的机制及应用做一综述,以供实验研究及临床参考。
Prostate cancer is an epithelial malignant tumor that occurs in the prostate. It is the most common cancer among men in the world. Its mortality rate is second only to lung cancer,which has seriously affected men’s healthy life. Prostate cancer is not easy to be detected in the early stage. Most patients are already in the advanced stage and metastasized when they are diagnosed. At this time,radical surgery is not suitable for treatment. Advanced prostate cancer is mainly treated with endocrine therapy,but after a median time of 14-30 months,the patient will develop hormone-resistant prostate cancer and enter the advanced stage. Advanced hormone-resistant prostate cancer is treated with radiotherapy and chemotherapy,which,however,are not ideal for treating advanced prostate cancer. They can also cause serious side effects such as frequent urination,dysuria,urinary incontinence,rectal bleeding,loss of libido,hot flashes,and impotence,as well as generate multi-drug resistance. Therefore,it ′s urgent to find a safe,effective and low-toxic anti-tumor drug. With the deepening of the research on the pharmacological effects of peptides,it has been proved that peptides have important application value in anti-fatigue,anti-aging,anti-inflammatory,antibacterial and anti-tumor. The anti-tumor peptides have attracted extensive attention in the field of anti-tumor research due to their high specificity, high bioavailability, good stability, low toxicity, low molecular weight, and easy synthesis.Pharmacological experiments have shown that polypeptides exert their anti-tumor effect mainly by inducing cell apoptosis,causing cell cycle arrest,inhibiting angiogenesis,and regulating immune function. This article summarized the related literature of peptides in recent years,the sources of peptides,the mechanisms and applications of peptides against prostate cancer for experimental research and clinical reference.
作者
李斌
刘旭
王洪颖
王彧
LI Bin;LIU Xu;WANG Hong-ying;WANG Yu(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Chinese People's Liberation Army Joint Logistics Support Force Sanatorium and Rehabilitation Center,Tianjin 300191,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第10期222-230,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(82004092)。
关键词
抗肿瘤多肽
前列腺癌
作用机制
研究进展
anti-tumor peptides
prostate cancer
mechanism
research progress
