摘要
目的:探究激素替代治疗对绝经前子宫切除术后出现围绝经期症状患者血清性激素、骨性碱性磷酸酶(BALP)水平及体质指数(BMI)影响。方法:选取2017年2月—2019年3月本院收治的绝经前行子宫切除术且术后6个月出现围绝经期症状患者76例,采用随机数字表法分为观察组与对照组,对照组采用替勃龙片、观察组采用戊酸雌二醇片分别进行激素替代治疗,对比两组治疗6个月后BMI、性激素水平、BALP水平及卵巢功能指标。结果:治疗3个月后,观察组血清雌二醇(71.46±4.53pg/ml)高于对照组(65.80±5.42pg/ml),BALP水平(15.64±4.31μg/ml)低于对照组(21.57±5.74μg/ml),卵泡刺激素(7.83±1.62mU/ml)低于对照组(9.25±1.78mU/ml)(均P<0.05);两组窦状卵泡数均减少,但观察组(7.65±1.23个)多于对照组(5.51±1.04个)(P<0.05),两组BMI及子宫体积与治疗前及组间比较均无差异(P>0.05)。结论:激素替代治疗可有效改善绝经前子宫切除术且术后出现围绝经期症状患者雌激素水平与骨代谢,抑制卵巢功能下降,且未增加肥胖发生率。
Objective:To explore the influence of hormone replacement therapy for treating women with premenopausal symptom after premenopause hysterectomy on their postoperative sex hormone level,serum bone alkaline phosphatase(BALP)level,and body mass index(BMI)value.Methods:76 women with premenopausal symptom after premenopause hysterectomy were selected and randomly divided into observation group and control group from February 2017 to March 2019.The women in the control group had received tibolone,and the women in the observation group had received estradiol valerate.The BMI value,sex hormone level,and serum BALP level,and other ovarian function index of women after 6 months treatment were compared between the two groups.Results:After 3 months of treatment,serum E2 level of women in the observation group(71.46±4.53pg/ml)was significant higher than that(65.80±5.42pg/ml)of women in the control group,but the levels of BALP and follicle stimulating hormone of women in the observation group(15.64±4.31μg/ml and 7.83±1.62mU/ml)were significant lower than those(21.57±5.74μg/ml and 9.25±1.78mU/ml)of women in the control group(all P<0.05).The number of sinus follicle of women in the two groups had decreased significantly,but that of women in the observation group(7.65±1.23)was significant higher than that(5.51±1.04)of women in the control group(P<0.05).There were no significant differences in the values of BMI and uterine volume of women between the two groups and between before and after treatment(P>0.05).Conclusion:Hormone replacement therapy can effectively improve the level of estrogen and bone metabolism of women with premenopausal symptom after premenopause hysterectomy,and can improve the decline of their ovarian function without increasing the incidence of obesity.
作者
王若茜
刘莹
刘永奇
WANG Ruoxi;LIU Ying;LIU Yongqi(Longwan District Hospital of Traditional Chinese and Western Medicine,Wenzhou,Zhejiang Province,325000)
出处
《中国计划生育学杂志》
2021年第2期262-265,共4页
Chinese Journal of Family Planning
关键词
子宫切除术后
激素替代治疗
性激素
骨性碱性磷酸酶
体质指数
卵巢功能
Hysterectomy
Hormone replacement therapy
Sex hormone
Bone alkaline phosphatase
Body mass index
Ovarian function
