摘要
目的分析代谢综合征(MS)患者血清生长分化因子15(GDF-15)水平与炎症、血脂谱的相关性。方法采用横断面研究,纳入MS患者131例,及162例同期体检健康人群作为对照组。酶联免疫吸附法检测血清GDF-15、白细胞介素6(IL-6)、单核细胞趋化蛋白1(MCP-1)水平。结果与对照组比较,MS组血清GDF-15水平显著升高[289.74(187.22,411.56)ng/L比159.30(114.13,245.87)ng/L,P<0.01],且随MS代谢组分数量增加呈升高趋势(P<0.01);在所有人群中,血清GDF-15水平与肥胖相关参数(体质指数、腰围、体脂百分比)、不良血脂谱(甘油三酯增加和高密度脂蛋白胆固醇降低)、空腹血糖、胰岛素抵抗指数(空腹胰岛素和HOMA-IR)及炎症标志物(MCP-1和IL-6)均呈显著正相关(P<0.05);年龄、高密度脂蛋白胆固醇和IL-6为血清GDF-15的独立相关因素;在调整混杂因素后,血清GDF-15水平与MS及血脂异常发生风险独立正相关,风险比分别为1.438(1.093,2.063)(P=0.018)、1.003(1.000,1.007)(P=0.043)。结论血清GDF-15水平在MS患者中显著升高,且与机体炎症和血脂谱密切相关,提示GDF-15可能参与了MS发生的病理机制及未来心血管疾病发生的潜在预测价值。
Aim To explore the relationship between serum growth differentiation factor-15(GDF-15)and inflammation,lipid metabolism in patients with metabolic syndrome(MS).Methods A total of 131 patients with MS were recruited as metabolic syndrome group,and 162 healthy people were enrolled as the healthy control group.The levels of serum GDF-15,interleukin-6(IL-6)and monocyte chemoattractant protein-1(MCP-1)were measured by enzyme-linked immunosorbent assay(ELISA).Results Serum GDF-15 levels were significantly higher in subjects with MS than those in the controls(289.74(187.22,411.56)ng/L vs 159.30(114.13,245.87)ng/L,P<0.01),and showed an increasing trend with the increased numbers of metabolic components(P<0.01).In all studied subjects,serum GDF-15 levels were positively correlated with obesity related parameters(body mass index,waist circumference,fat percentage,P<0.05),an adverse lipid profile(triglyceride(TG)increased and high density lipoprotein cholesterol(HDLC))decreased,P<0.05),fasting plasma glucose,insulin resistance index(fasting serum lisulin(FINS)and homeostasis model assessment for insulin resistance(HOMA-IR))and inflammatory markers(MCP-1 and IL-6).Age,HDLC,IL-6 were independent factors for GDF-15 levels.After adjusting for potential confounders,GDF-15 remained an independent risk factor for MS and dyslipidemia,and the associated odds ratios were 1.438(1.093,2.063)and 1.003(1.000,1.007)respectively(P=0.018 and P=0.043).Conclusion The levels of serum GDF-15 were significantly higher in patients with MS,and GDF-15 was closely related to the inflammation and lipid profile,which suggested that GDF-15 may be involved in the pathogenesis of MS and the potential predictive value of cardiovascular disease in the future.
作者
麦云妮
李骄阳
张卓
王亚荻
廖哲珍
齐潇雁
冉莉
杨靖
刘江华
肖新华
MAI Yunni;LI Jiaoyang;ZHANG Zhuo;WANG Yadi;LIAO Zhezhen;QI Xiaoyan;RAN Li;YANG Jing;LIU Jianghua;XIAO Xinhua(Department of Metabolism and Endocrinology,the First Affiliated Hospital of University of South China,Hengyang,Hunan 421001,China)
出处
《中国动脉硬化杂志》
CAS
2021年第5期400-404,共5页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金(81870595)
湖南省卫计委重大专项课题(A2017011)。
