摘要
感染性骨缺损是高能量创伤、骨髓炎及内置物感染后出现的严重并发症,成为骨科最难治疗的疾病之一,而生物膜的形成是感染性骨缺损的重要因素。随着富血小板血浆(PRP)在骨科及其他领域的广泛应用并取得成功,PRP具有的抗菌和促愈合能力使其能够作为新型生物材料负载抗生素并成为感染性疾病包括感染性骨缺损的新治疗手段。笔者从PRP负载抗生素联合Masquelet技术的优势、手术方式、适应证及操作要点等方面进行阐述,为临床治疗感染性骨缺损提供参考。
Infectious bone defect is a serious complication after high-energy trauma,osteomyelitis and infection of implants.It has become one of the most difficult diseases in orthopedics.The formation of bioflm is an important factor of infectious bone defect.W ith the wide application and success of platelet-rich plasma(PRP)in orthopedics and other fields,PRP can be used as a new biomaterial to load antibioties and become a new treatment method for infectious diseases,including infectious bone defects.The authors discuss the characterstics of PRP-loaded antibiotics combined with Masquelet technique in treatment of infectious bone defect from the aspects of advantages,operation points,indications and operation methods,so as to provide references for treatment of infectious bone defect in clinic.
作者
费军
薛超
Fei Jun;Xue Chao(Department of Emergency,Duping Hospital,State Key Laboratory of Trauma,Burns and Combined Injury,Army Medical University,Chongqing 400042,China;Department of Orthopedics,First Affiliated Hospital of Chinese PLA General Hospital,Beijing 100048,China)
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2021年第4期295-300,共6页
Chinese Journal of Trauma
基金
陆军军医大学优秀人才库重点扶持对象
重庆市科委课题(218ZDXMO3O)。
关键词
富血小板血浆
抗菌药
生物膜
葡萄球菌
金黄色
骨重建
Platelet-rich plasma
Anti-bacterial agents
Biofilms
Staphylococcus aureus
Bone remodeling
