摘要
目的分析PubMed中迷走神经刺激疗法(VNS)的临床研究文献,总结其研究现状和临床特点,为其研究提供借鉴和参考。方法在PubMed中检索1990年1月—2020年6月发表的所有VNS文献,采用CiteSpace软件进行作者、国家、机构、期刊、关键词共现分析,并绘制相关可视化图谱;通过信息提取并绘制表格,对VNS的疾病谱、治疗效果、刺激方式和参数等临床特点进行总结分析。结果共纳入138篇文献。发文量最多的作者为朱兵;发文量前三位的国家为美国(75篇)、德国(26篇)、荷兰和英国(皆14篇);发文量最多的机构为中国中医科学院(7篇)、ElectroCore公司(7篇)和明尼苏达大学(7篇)。论文分别发表于78本期刊,刊文前两位为Epilepsia(11篇)和Neurology(10篇)。VNS治疗癫痫和抑郁症的相关研究是研究热点。研究共涉及27种疾病,癫痫、抑郁症、偏头痛最多;文献中选用的设备主要为植入式和经皮式刺激;刺激频率低频为主,参数随疾病和刺激方式而定。结论VNS对神经精神系统疾病具有很好的疗效,尤其是癫痫和抑郁症;国内耳部VNS的研究水平处于相对领先地位;非植入式VNS将成为新的研究和发展方向。
Objective To analyze the clinical research literature of vagal nerve stimulation(VNS)in PubMed,summarize its research status and clinical characteristics,so as to provide reference for its research.Methods All literatures about VNS included in PubMed from January 1990 to June 2020 were retrieved,the co-occurrence analysis of authors,countries,institutions,journals and keywords were carried out by using CiteSpace software.Through information extraction and table drawing,the clinical characteristics of VNS,such as disease spectrum,therapeutic effect,stimulation mode and parameters were summarized and analyzed.Results A total of 138 literatures were included.The author who published the most articles was Zhu Bing;the top three countries were USA(75 articles),Germany(26 articles),Netherlands and UK(all 14 articles);the most published institutions were China Academy of Chinese Medical Sciences(7 articles),Electrocore(7 articles)and Minnesota University(7 articles).It was published in 78 journals,and the top two magazines were Epilepsia(11 articles)and Neurology(10 articles).The related research of VNS in the treatment of epilepsy and depression were research hotspot.The study involved 27 diseases,of which epilepsy,depression and migraine had the largest number;the main stimulation methods were implantable and percutaneous;and the main frequency of stimulation was low frequency,and the parameters depend on the disease and the mode of stimulation.Conclusion VNS has a good effect on neuropsychiatric diseases,especially epilepsy and depression.The research level of ear VNS is in the leading position in China.Non-implantable VNS will become a new research and development direction.
作者
郑嘉元
蒋静
钱晨蕾
庄艺
卢圣锋
ZHENG Jiayuan;JIANG Jing;QIAN Chenlei;ZHUANG Yi;LU Shengfeng(Key Laboratory of Acupuncture and Medicine Research of Ministry of Education,Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing 210023,China;School of Acupuncture and Massage,School of Regimen and Rehabilitation,Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing 210023,China;Institute of Scientific and Technical Information of China,Beijing 100038,China)
出处
《中国医药导报》
CAS
2021年第7期18-22,共5页
China Medical Herald
基金
国家自然科学基金面上项目(81774210)
江苏省“六大人才高峰”高层次人才选拔培养资助项目(YY-033)
江苏省“333高层次人才培养工程”培养对象
江苏省高等学校大学生创新创业训练计划项目(201910315065Y)。
