摘要
目的探讨强直性脊柱炎(AS)合并颈椎骨折的病理特点及其预后情况。方法选取2014年1月至2019年12月本院AS患者20例为对照组,AS合并颈椎骨折患者20例为观察者,使用酶联免疫法对两组患者检测CTX-I,使用免疫比浊法检测CRP,放射免疫法对BGP进行检测,通过WB检测异位骨化相关因子,通过CT及MRI检查分析颈椎骨折患者的损伤程度,以此总结其病理特点,并对患者治疗后的预后情况进行记录。结果观察者CRP与CTX-1水平均高于对照组(P<0.05),BGP低于对照组(P<0.05);观察者SOST、DKK-1均较低(P<0.05),而BMP-7则较高(P<0.05),即观察者成骨功能较对照组弱。通过CT及MRI检查,得出AS合并颈椎骨折具有脊柱骨性强直、椎体骨质疏松,易增加脊椎骨的脆性程度等特点;而通过Frankel分级以及VAS评分,得出手术治疗对于患者的预后具有改善效果。结论AS合并颈椎骨折患者具有病程长,全身功能情况较差,脊椎骨坚硬程度较差、脊髓易损伤等特点,但通过手术治疗其预后能够得到有效改善。
Objective To investigate the pathological features and prognosis of ankylosing spondylitis with cervical spine fracture.Method CTX-I was detected by enzyme-linked immunosorbent assay(ELISA),CRP was detected by immunoturbidi-metry,BGP was detected by radioimmunoassay,and osteogenesis was compared between the two groups.The heterogeneous ossification related factors were detected,and the degree of injury was investigated by CT and MRI.The pathological characteristics were summarized and the prognosis of the patients was recorded.Results By detecting the relevant indicators of the patients,we found that the CRP and CTX-I levels in the experimental group were higher than those in the control group(P<0.05),and the BGP was lower than the control group(P<0.05).The ossification related factors were detected,and the SOST and DKK-1 of the experimental group were lower(P<0.05),while the BMP-7 was higher(P<0.05),that is,the osteogenesis function of the experimental group was better than that of the control group.The group is relatively weak.In order to explore its pathological features,through CT and MRI,we have found that ankylosing spondylitis with cervical spine fractures has osteoporosis of the spine,osteoporosis of the vertebral body,and it is easy to increase the brittleness of the vertebrae;and by Frankel Grading and VAS scores show that the surgical treatment has an effective improvement effect on the prognosis of the patient.Conclusion Such patients have long-term disease,poor systemic function,poor spine stiffness,and easy spinal cord injury,but their prognosis can be effectively improved by surgery.
出处
《浙江临床医学》
2021年第3期341-343,共3页
Zhejiang Clinical Medical Journal
基金
湖州市科学技术局自然科学资金项目(2016YZB03)。
关键词
强直性脊柱炎合并颈椎骨折
病理特点
预后
Ankylosing spondylitis with cervical spine fracture
Pathological features
Prognosis
