摘要
目的分析注射用甲磺酸齐拉西酮治疗双相Ⅰ型障碍躁狂发作急性激越症状的疗效和安全性。方法选取2019年4月至2020年4月本院收治的60例双相Ⅰ型障碍躁狂发作急性激越症状患者,按治疗方式的不同分为两组,各30例。对照组采用氟哌啶醇注射液治疗,研究组采用甲磺酸齐拉西酮注射液治疗。比较两组不良反应发生率、阳性与阴性症状量表兴奋因子(PANSS-EC)评分、临床疗效总评量表-病情程度(CGI-SI)评分等。结果治疗后,研究组CGI-SI评分略低于对照组,但差异无统计学意义;治疗前及治疗后2、6、24、48、72 h两组PANSSEC评分比较差异无统计学意义;研究组不良反应总发生率为6.67%,低于对照组的43.33%,差异有统计学意义(P<0.05)。结论与氟哌啶醇注射液比较,临床采用注射用甲磺酸齐拉西酮药物治疗双相Ⅰ型障碍躁狂发作急性激越症状,虽疗效基本相当,但给药安全性更高,对疾病治疗有利。
Objective To analyze the efficacy and safety of zilacetone mesylate for injection in the treatment of acute agitation symptoms of bipolar disorder mania with I disorder.Methods From April 2019 to April 2020,60 patients with acute agitation symptoms of bipolar disorder mania withⅠdisorder were divided into two groups,with 30 cases in each group.The control group was treated with haloperidol injection and the study group was treated with zilacetone mesylate injection.The adverse reactions,positive and negative symptom scale excitatory factor(PANSS-EC)score,total clinical efficacy scale-degree of illness(CGI-SI)score were compared between the two groups.Results After treatment,the CGI-SI score of the study group was slightly lower than that of the control group,but the difference was not statistically significant.There was no significant difference in PANSS-EC scores between the two groups before treatment and 2 h,6 h,24 h,48 h,72 h after treatment.The total incidence of adverse reactions in the study group was 6.67%,which was lower than 43.33%in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with haloperidol injection,zilacetone mesylate was used to treat acute agitation symptoms of bipolar disorder mania with I disorder.Although the curative effect was basically the same,the safety of administration was higher,which was beneficial to the treatment of disease.
作者
李启洪
唐京雄
吴锦华
LI Qihong;TANG Jingxiong;WU Jinhua(Department of Psychiatry,Third People's Hospital of Xinhui District,Jiangmen City,Jiangmen,Guangdong,529100,China)
出处
《当代医学》
2021年第9期84-86,共3页
Contemporary Medicine
关键词
注射用甲磺酸齐拉西酮
氟哌啶醇注射液
双相Ⅰ型障碍躁狂
急性激越症状
Zilacetone mesylate for injection
Haloperidol injection
Bipolar disorder mania withⅠdisorder
Acute agitation symptoms
