摘要
目的研究B(A)血型的血清学特点及分子生物学遗传特性。方法采用血型血清学及ABO血型基因检测方法,对先证者及其家庭成员共9人完成ABO亚型分析及家系遗传规律调查。将B(A)血型标本作为受血者,采用微柱凝胶抗球蛋白法为其选择B型和O型供者进行交叉配血,评估其输血策略。结果 9例标本中5例为B(A)表现型,携带有B(A)04等位基因。其中,1例为B(A)04/O1型,4例为B(A)04/B型。B(A)血型标本与B型和O型受血者主侧配血均为阴性。结论该B(A)血型家系调查中共发现B(A)04血型5例,且血清学表现存在差异,B(A)血型红细胞输血可选择B型和O型洗涤红细胞,紧急情况可考虑B型悬浮红细胞输注。
Objective To study the serological and genetic characteristics of a case of B(A) blood group. Methods Serological and genetic ABO blood group typing were used to analyze the ABO subtype and family inheritance of the probands and her 8 family members. The B(A) blood type sample was used as the blood recipient, and the B-type and O-type donors were selected for cross-matching using microcolumn gel anti-human globulin method to evaluate the blood transfusion strategy. Results 5 out of 9 family blood samples were B(A) phenotype, carrying B(A)04 allele. Among them, 1 was B(A)04/O1 type, and 4 were B(A)04/B type. The primary blood matching of B(A) blood type samples with type B and O recipients were all negative. Conclusion A total of 5 cases of B(A)04 blood type were found in this family investigation, and there were differences in serological manifestations. Washed RBCs with B and O type can be used for B(A) blood type transfusion, and type B suspended RBCs can be considered in case of emergency.
作者
付丽辉
马春娅
孙晓琳
吴月清
于洋
汪德清
FU Lihui;MA Chunya;SUN Xiaolin;WU Yueqing;YU Yang;WANG Deqing(Department of Blood Transfusion,First Medical Center,Chinese People's Liberation Army General Hospital,Beijing 100853,China;Department of Blood Transfusion,Hainan Hospital,Chinese People's Liberation Army General Hospital)
出处
《中国输血杂志》
CAS
2021年第2期188-190,共3页
Chinese Journal of Blood Transfusion
关键词
B(A)
血型
血清学
基因分型
家系调查
B(A)
blood group
serological typing
genetic typing
family study
