摘要
目的探讨围生期孕妇无乳链球菌(GBS)的临床感染情况及耐药性特征,为临床合理使用抗菌药物提供参考。方法对2017年4月至2020年3月在该院产检的围生期孕妇6313例进行GBS检测,根据检测结果分为GBS阳性组和GBS阴性组,比较2组孕妇的一般资料及妊娠结局,分析GBS对10种抗菌药物的耐药率。结果6313例围生期孕妇中,GBS感染率为7.16%(452/6313);2组孕妇年龄,妊娠期糖尿病、妊娠期高黏稠血症、妊娠期阴道炎检出率比较,差异无统计学意义(P>0.05),2组双胎妊娠、不良孕史比较,差异有统计学意义(P<0.05);2组在早产、羊水污染、产后出血、剖宫产率方面比较,差异无统计学意义(P>0.05),2组胎儿窘迫、先兆流产、胎膜早破发生率比较,差异有统计学意义(P<0.05)。分离出的452株GBS对利奈唑胺、青霉素、奎奴普丁/达福普汀、替加环素、万古霉素、替考拉宁、氨苄西林敏感率为100.00%,对克林霉素、左氧氟沙星、四环素的敏感率分别为28.98%、44.91%、67.92%。结论围生期孕妇GBS感染易造成胎儿窘迫、先兆流产及胎膜早破等不良妊娠结局,临床上应加强围生期孕妇GBS感染的防控工作,目前青霉素仍是治疗GBS的首选药物。
Objective To investigate the clinical infection and drug resistance characteristics of Streptococcus agalactiae(GBS)in perinatal pregnant women,and to provide references for the clinical rational use of antimicrobials.Methods A total of 6313 cases of perinatal pregnant women in the hospital from April 2017 to March 2020 were tested for GBS.According to the test results,they were divided into the GBS positive group and the GBS negative group.The general conditions and pregnancy outcomes of the two groups were compared,and the drug resistance rate of GBS to 10 antimicrobials was analyzed.Results Among 6313 perinatal pregnant women,the GBS infection rate was 7.16%(452/6313).There were no statistically significant differences in the age,the detection rates of gestational diabetes,hyperviscosity of pregnancy and vaginitis during pregnancy in the two groups of pregnant women(P>0.05).There were statistically significant differences in twin pregnancy and adverse pregnancy history between the two groups(P<0.05).There were no statistically significant differences between the two groups interms of premature delivery,amniotic fluid contamination,postpartum hemorrhage,and cesarean section rates(P>0.05).There were statistically significant differences in fetal distress,threatened abortion,and premature rupture of membranes between the two groups(P<0.05).The drug susceptibility rates of the 452 strains of isolated GBS to linezolid,penicillin,quinupristin/dalfopristin,tigecycline,vancomycin,teicoplanin and ampicillin were 100.00%,and the drug susceptibility rates to clindamycin,levofloxacin and tetracycline were 28.98%,44.91%and 67.92%,respectively.Conclusion The GBS infection in perinatal pregnant women is easy to cause adverse pregnancy outcomes such as fetal distress,threatened abortion and premature rupture of membranes.The prevention of GBS infection in perinatal pregnant women should be strengthened clinically.Penicillin is still the first choice for the treatment of GBS.
作者
丁赔赔
李艳君
丁毅伟
钱扬会
赵强元
DING Peipei;LI Yanjun;DING Yiwei;QIAN Yanghui;ZHAO Qiangyuan(Department of Clinical Laboratory,the Six Medical Center of PLA General Hospital,Beijing 10048,China)
出处
《检验医学与临床》
CAS
2021年第5期603-606,共4页
Laboratory Medicine and Clinic
基金
解放军总医院第六医学中心创新培育基金(CXPY201915)。
关键词
围生期孕妇
无乳链球菌
妊娠结局
耐药性
perinatal pregnant women
Streptococcus agalactiae
pregnancy outcomes
drug resistance
