摘要
目的探讨血清学联合超声参数预测子痫前期(PE)的临床应用价值。方法选取本院2016年4月至2019年4月收治的PE高危因素产妇200例设为PE组对象,按照随机数字表法分为对照组和治疗组,各100例;选取同期PE高危因素产妇里通过随访妊娠结局确定血压正常的产妇200例设为血压正常组。对照组实施常规治疗,治疗组在对照组基础上给予补钙与阿司匹林的对症治疗。比较血压正常组与PE组动脉血流参数,治疗前后对照组与治疗组炎症因子TNF-α与血清钙浓度变化情况。结果血压正常组胎儿大脑中动脉(MCA)波动指数(PI)和阻力指数(IR)高于PE组,脐动脉与子宫动脉PI与IR低于PE组,差异有统计学意义(P<0.05)。治疗前,对照组与观察组炎症因子TNF-α与血清钙浓度比较差异无统计学意义;治疗后,两组炎症因子TNF-α降低,血清钙浓度升高,且观察组比对照组改善更显著,差异有统计学意义(P<0.05)。治疗组胎儿MCA的PI与IR高于对照组,脐动脉与子宫动脉PI与IR低于对照组,差异具有统计学意义(P<0.05)。结论应用血清学联合超声参数中的胎儿MCA和子宫动脉血流检测可预测PE,能及早进行预防,有效改善患者体内炎症因子TNF-α水平与血清钙浓度,从而减少新生儿疾病与产妇死亡的发生。
Objective To study the prediction of preeclampsia(PE)by detection of serology and prediction of ultrasonic parameters.Methods 200 parturient women with PE who were admitted to the hospital between April 2016 and April 2019 were included in PE group.They were divided into the control group and the treatment group by the random number table method,with 100 cases in each group.200 parturient women with normal blood pressure confirmed by follow-up pregnancy outcomes were selected from parturient women with PE and they were included in the normal blood pressure group.The control group was given routine treatment,and the treatment group was given symptomatic treatment of calcium supplementation and aspirin on the basis of the treatment for control group.The arterial blood flow parameters were compared between the normal blood pressure group and PE group.Changes of inflammatory factor TNF-αand serum calcium concentration before and after treatment were compared between the control group and the treatment group.Results The pulsation index(PI)and resistance index(IR)of fetal middle cerebral artery(MCA)and maternal cerebral artery in the normal blood pressure group were higher than those in PE group,while PI and IR of umbilical artery and uterine artery were lower than PE group(P<0.05).There was no significant difference in the concentration of inflammatory factor TNF-αor serum calcium between the control group and the observation group before treatment.After treatment,the inflammatory factor TNF-αdecreased,and serum calcium concentration increased in both groups.Besides,the improvement was more obvious in the observation group than in the control group(P<0.05).The PI and IR of maternal MCA in the treatment group were higher than those in the control group,while the umbilical artery and uterine artery PI and IR were lower than the control group(P<0.05).Conclusion Using serology and prediction of ultrasonic parameters to predict PE is conductive to early prevention,effective improvement of the level of inflammatory factor TNF-αand serum calcium in patients,thereby reducing neonatal morbidity and maternal mortality.
作者
马彦超
MAYanchao(Department of Obstetrics And Gynecology,Heze Municipal Hospital,Heze,Shandong,274031,China)
出处
《当代医学》
2021年第7期36-38,共3页
Contemporary Medicine
关键词
血清学
子宫动脉血流
子痫前期
Serology
Uterine artery blood flow
Preeclampsia
