摘要
目的探讨C-反应蛋白(CRP)、降钙素原(PCT)和白细胞介素-6(IL-6)诊断小儿开放性胃肠手术术后感染的临床价值。方法选取贵州省人民医院2017年5月-2019年5月行开放性胃肠手术患儿256例,根据术后是否发生感染分为感染组32例,非感染组224例。选取40名同期健康体检儿童为对照组。检测三组研究对象血清CRP、PCT和IL-6水平并进行比较,比较感染组与非感染组中CRP、PCT、IL-6阳性检出率,分析各指标单独及联合测定诊断小儿开放性胃肠手术术后感染中的价值。结果三组研究对象血清CRP、PCT、IL-6水平比较差异具有统计学意义(P<0.05),感染组与非感染组患儿血清CRP、PCT、IL-6水平均高于对照组(P<0.05),与非感染组比,感染组患儿血清CRP、PCT、IL-6水平更高(P<0.05);感染组CRP、PCT、IL-6指标单独及联合检测阳性检出率均高于非感染组(P<0.05);血清CRP、PCT、IL-6联合诊断术后感染的特异性为94.98%、灵敏度为97.62%、阳性预测值为95.37%、阴性预测值为93.19%。结论开放性胃肠手术术后感染患儿血清CRP、PCT和IL-6水平升高,可用于预测小儿开放性胃肠手术术后感染,且三指标联合的诊断效能更好。
OBJECTIVE To explore the clinical value of C-reactive protein(CRP),procalcitonin(PCT)and interleukin-6(IL-6)in diagnosis of postoperative infections in the children undergoing open gastrointestinal surgery.METHODS A total of 256 children who underwent open gastrointestinal surgery in Guizhou People′s Hospital from May 2017 to May 2019 were enrolled in the study and divided into the infection group with 32 cases and the non-infection group with 224 cases according to the status of infection,meanwhile,40 healthy children who received physical examination were set as the control group.The levels of serum CRP,PCT and IL-6 were compared among the three groups of study subjects,the positive rates of CRP,PCT and IL-6 were compared between the infection group and the non-infection group,and the values of single index and their combination in diagnosis of postoperative infection were observed.RESULTS There were significant differences in the levels of serum CRP,PCT and IL-6 among the three groups of study objects(P<0.05);the levels of serum CRP,PCT and IL-6 of the infection group and the non-infection group were significantly higher than that of the control group(P<0.05);the levels of serum CRP,PCT and IL-6 of the infection group were significantly higher than those of the non-infection group(P<0.05).The positive rates of single and joint detection of CRP,PCT and IL-6 of the infection group were significantly higher than those of the non-infection group(P<0.05).The specificity of the joint detection of serum CRP,PCT and IL-6 was 94.98%in diagnosis of postoperative infection,the sensitivity 97.62%,the positive predictive value 95.37%,the negative predictive value 93.19%.CONCLUSION The levels of serum CRP,PCT and IL-6 of the open gastrointestinal surgery children with postoperative infection are elevated,which can be used for prediction of the postoperative infection;the diagnostic efficiency of the joint detection of the three indexes is better.
作者
范霞
李飞
罗淼
覃智杰
FAN Xia;LI Fei;LUO Miao;QIN Zhi-jie(Guizhou People's Hospital,Guiyang,Guizhou 550001,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2020年第24期3793-3796,共4页
Chinese Journal of Nosocomiology
