摘要
目的分析β2-MG、UACR及Cys-C对原发性老年高血压肾损伤的预测价值研究。方法选取2017年1月至2020年1月本院接收的90例原发性老年高血压患者临床资料,为研究组,根据是否合并肾损伤分为两组,将合并肾损伤者设为A组(n=52)例,将未合并肾损伤者设为B组(n=38)例;同时选取64例同期健康体检人群作为对照组。对比不同人群β2-MG、UACR及Cys-C水平;采用多元Logistic回归分析影响原发性老年高血压合并肾损伤的独立危险因素;应用ROC曲线分析β2-MG、UACR及Cys-C对原发性老年高血压合并肾损伤的预测价值。结果研究组患者β2-MG、UACR及Cys-C水平高于对照组,差异有统计学意义(P<0.05);A组患者β2-MG、UACR及Cys-C水平高于B组,差异有统计学意义(P<0.05);通过Logistic回归模型分析影响原发性老年高血压合并肾损伤的相关因素,得出:收缩压、舒张压、β2-MG、UACR、Cys-C、血脂异常为影响原发性老年高血压合并肾损伤的单因素(P<0.05),进一步分析发现舒张压异常、收缩压异常、β2-MG、UACR、Cys-C异常升高为影响原发性老年高血压合并肾损伤的独立危险因素(P<0.05);β2-MG、UACR、Cys-C及三者联合约登指数分别为0.626、0.638、0.624、0.788;β2-MG、UACR、Cys-C及三者联合曲线下面积分别为0.699、0.821、0.712、0.923,各指标曲线下面积以联合检测最大。结论β2-MG、UACR及Cys-C水平异常是影响原发性老年高血压合并肾损伤的独立危险因素,联合指标检测对评估患者病情有重要价值。
Objective To analyze the predictive value of β2-MG,UACR and Cys-C on renal damage of patients with senile primary hypertension.Methods The clinical data of 90 patients with senile primary hypertension treated in our hospital from January 2017 to January 2020 were selected and were set as the research group.They were divided into two groups according to whether they had kidney injury or not.Those with renal injury were set as group A(n=52),and those without renal injury were set as group B(n=38).At the same time,64 cases with healthy physical examination during the same period were selected as the control group.The levels of β2-MG,UACR and Cys-C in different people were compared.Multivariate Logistic regression analysis was used to analyze the independent risk factors affecting senile primary hypertension combined with renal injury.The ROC curve was used to analyze the predictive value ofβ2-MG,UACR and Cys-C for senile primary hypertension combined with renal injury.Results The levels of β2-MG,UACR,and CysC in the research group were higher than those in the control group(P<0.05).The levels of β2-MG,UACR and Cys-C in group A were higher than those in group B,difference was statistically significant(P<0.05).The logistic regression model is used to analyze the related factors that affect primary elderly hypertension with renal injury,and it is concludedthat systolic blood pressure,diastolic blood pressure,β2-MG,UACR,Cys-C,and dyslipidemia were the single factors that affect senile primary hypertension combined with renal injury(P<0.05).Further analysis revealed that abnormal diastolic blood pressure,abnormal systolic blood pressure,abnormal increasing ofβ2-MG,UACR,and Cys-C were independent risk factors affecting senile primary hypertension combined with renal injury(P<0.05).The Youden Index of β2-MG,UACR,Cys-C and the combination of them were 0.626,0.638,0.624,and 0.788,respectively.The area under the curve of β2-MG,UACR,Cys-C and the three combined curves were 0.699,0.821,0.712,0.923,respectively,and the area under the combined curve was the highest.Conclusion Abnormal levels of β2-MG,UACR,and Cys-C are independent risk factors that affect senile primary hypertension combined with renal injury.The detection of combined indicators is of great value in evaluating the patient's condition.
作者
周敏
薛文翠
马玮龙
李霞
于红蕾
ZHOU Min;XUE Wencui;MA Weilong;LI Xia;YU Honglei(Department of Geriatrics,Qinhuangdao Military Hospital,Qinhuangdao,Hebei,China,066000)
出处
《分子诊断与治疗杂志》
2021年第1期115-118,共4页
Journal of Molecular Diagnostics and Therapy
基金
秦皇岛市科学技术研究与发展计划(201805A105)。
