摘要
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的新型冠状病毒肺炎(COVID-19)已成为国际关注的突发公共卫生事件.SARS-CoV-2的传播、致病机制、疫苗研发等成为当前研究焦点,其感染可诱导宿主靶细胞中病原体相关分子模式(PAMPs)和损伤相关分子模式(DAMPs)激活、介导细胞器损伤和细胞毒性作用,并通过诱发级联免疫炎症反应介导组织器官的损伤等,该过程的毒理学机制和生物标志亟待阐明.该文从SARS-CoV-2进入宿主、作用于不同靶细胞出发,聚焦于信号通路分子、细胞器、细胞和靶器官等毒性通路的级联作用模式,总结SARS-CoV-2感染诱导毒性作用效应的研究进展,为探索环境生物因素暴露(如冠状病毒感染)诱导机体毒性损伤的靶点筛查、靶向干预及其应用于毒理学安全性评价提供参考.
Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has become a public health emergency of international concern.The virus transmission,pathogenic mechanism,and vaccine development,etc.have become the hot topic of research currently.However,the toxicological mechanisms and biomarkers in tissue and organ damage mediated by cascade immune inflammation,which is induced by SARS-CoV-2 infection via activation of pathogen-associated molecular patterns(PAMPs)and damage-associated molecular patterns(DAMPs),organelle damages and cytotoxicity,need to be clarified.In this paper,we aimed at taking SARS-CoV-2 enter the host and act on different target cells as the starting point,with the focus on the cascade mode of toxic pathways in signaling molecules,organelles,cells,target organs,etc.We also summarized the research advances in the study of SARS-CoV-2 infection-induced toxicity effects,which provides references in exploring the targeted screening and interventions of physical toxicity induced by environmental biological factors(such as coronavirus infection),and its application in the toxicological safety evaluation.
作者
车琳
兰尤
林锦贤
林育纯
CHE Lin;LAN You;LIN Jinxian;LIN Yuchun(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,School of Public Health,Xiamen University,Xiamen 361102,China)
出处
《厦门大学学报（自然科学版）》
CAS
CSCD
北大核心
2021年第1期1-13,共13页
Journal of Xiamen University：Natural Science
基金
国家自然科学基金(81874272,81973082)。
