摘要
目的观察杏芎氯化钠注射液佐治行经皮冠状动脉介入术(PCI)急性心肌梗死的临床疗效。方法选取医院2019年1月至9月收治的急性心肌梗死患者80例,按随机数字表法分为治疗组和对照组,各40例。两组患者均予常规治疗及PCI前口服硫酸氢氯吡格雷片和阿司匹林肠溶片;治疗组在PCI前加用杏芎氯化钠注射液;两组均连续治疗2周。结果治疗组总有效率为92.50%,显著高于对照组的67.50%(P<0.05);治疗后,治疗组患者血运再通时间显著短于对照组,左心室后壁厚度(LVPWT)、左心室收缩末期内径(LVESd)、左心室舒张末期内径(LVEDd)均显著小于对照组,血小板活化因子(PAF)、异构前列腺素、心肌肌钙蛋白T(c Tn T)、肌酸激酶同工酶(CK-MB)水平均显著低于对照组,左心室质量指数(LVMI),左心室射血分数(LVEF),血小板聚集率均显著小于对照组(P<0.05);治疗组患者住院期间主要不良心血管事件(MACE)发生率显著低于对照组(10.00%比20.00%,P<0.05)。结论杏芎氯化钠注射液佐治行PCI急性心肌梗死,可缩短血运再通时间,抑制心室重构,减轻心肌损伤,改善心功能,拮抗PAF,减少MACE的发生。
Objective To observe the clinical efficacy of Xingxiong Sodium Chloride Injection in the adjuvant treatment of acute myocardial infarction(AMI)after the percutaneous coronary intervention(PCI).Methods Totally 80 patients with AMI admitted to our hospital from January to September 2019 were selected and divided into the treatment group and the control group according to the random number table method,40 cases in each group.The patients in the two groups received conventional treatment and oral administration of Clopidogrel Bisulfate Tablets and Aspirin Enteric-Coated Tablets before PCI.On this basis,the patients in the treatment group were treated with Xingxiong Sodium Chloride Injection before PCI.Both groups were continuously treated for 2 weeks.Results The total effective rate of the treatment group was 92.50%,which was significantly higher than 67.50%of the control group(P<0.05).After treatment,the revascularization time,left ventricular posterior wall thickness(LVPWT),left ventricular end-systolic diameter(LVESd),left ventricular end-diastolic diameter(LVEDd)in the treatment group were significantly shorter than those in the control group,the levels of platelet-activating factor(PAF),isoprostaglandin,cardiac troponin T(c Tn T)and creatine kinase-MB(CK-MB)in the observation group were significantly lower than those in the control group,the left ventricular mass index(LVMI),left ventricular ejection fraction(LVEF)and platelet aggregation rate in the observation group were significantly lower than those in the control group(P<0.05).The incidence of major adverse cardiovascular events(MACE)in the treatment group was significantly lower than that in the control group(10.00%vs.20.00%,P<0.05).Conclusion Xingxiong Sodium Chloride Injection in the adjuvant treatment of AMI after PCI can shorten the time of revascularization,inhibit ventricular remodeling,reduce myocardial injury,improve cardiac function,antagonize PAF and reduce the occurrence of MACE.
作者
尚伟
张晓良
李玥
邱先狄
徐中林
王浩然
SHANG Wei;ZHANG Xiaoliang;LI Yue;QIU Xiandi;XU Zhonglin;WANG Haoran(Chongqing Ninth People's Hospital,Chongqing,China 400700)
出处
《中国药业》
CAS
2021年第2期49-52,共4页
China Pharmaceuticals
基金
重庆市科卫联合医学科研项目[2019QNXM036]。
关键词
心肌梗死
经皮冠状动脉介入术
杏芎氯化钠注射液
心室重构
心功能
血小板活化因子
脂质过氧化
辅助治疗
临床疗效
myocardial infarction
percutaneous coronary intervention
Xingxiong Sodium Chloride Injection
ventricular remodeling
cardiac function
platelet-activating factor
lipid peroxidation
adjuvant treatment
clinical efficacy
