摘要
目的探讨新型冠状病毒肺炎(COVID-19)患者外周血细胞的变化规律,为治疗和防范提供指导意义。方法对365例COVID-19患者在住院当天、住院3~7 d、住院14~21 d的白细胞、淋巴细胞等指标分别检测,对3个不同时间的检测结果进行比较,观察COVID-19患者随病程进展血细胞的动态改变。结果365例COVID-19患者在住院3~7 d时白细胞计数最低,均值为4.78×10^9/L,中性粒细胞百分比均值为67.77%,与住院当天和住院14~21 d比较,差异均有统计学意义(P<0.05),与正常对照比较,差异也均有统计学意义(P<0.01);COVID-19患者住院3~7 d的淋巴细胞计数均值为1.07×10^9/L,百分比均值为22.75%,与住院当天和住院14~21 d比较,差异均有统计学意义(P<0.05),与正常对照比较,差异也均有统计学意义(P<0.01)。结论365例COVID-19患者在住院3~7 d白细胞计数最低,而淋巴细胞计数的降低更为明显。经过综合治疗14~21 d后,白细胞和淋巴细胞计数较住院3~7 d及住院当天均有上升,但仍未恢复至正常水平。
Objective To investigate the change rule of peripheral blood cells in the patients with new type coronovirus pneumonia virus disease 2019(COVID-19)to provide the guidance significance for its treatment and prevention.Methods The indicators of WBC and lymphocytes were detected on the admission day,3-7 d and 14-21 d after admission in 365 cases of COVID-19.The detection results were compared among three different periods and the dynamic changes of blood cells with the disease condition progression in the patients with COVID-19 were observed.Results The WBC count on 3-7 d after admission in 365 cases of COVID-19 was the lowest,the average value was 4.78×10^9/L,the percentage of granulocytes was 67.77%,which were compared with those on admission day and 14-21 d after admission,the differences were statistically significant(P<0.05),and when compared with the normal control group,the difference also showed the statistical significance(P<0.01).The mean lymphocytes count on 3-7 d after admission was 1.07×10^9/L,the proportoin mean value was 22.75%,which were compared with those on the admission day and 14-21 d after admission,the differences were statistically significant(P<0.05),which were compared with those in the normal control group,the differences also had statistically significance(P<0.01).Conclusion In 365 patients with COVID-19,the WBC count was the lowest on 3-7 d after admission,while the decrease of lymphocytes count was more obvious.After 14-21 d comprehensive treatment,the WBC and lymphocytes count were increased compared with those on 3-7 d after admission and the admission day,but still did not return to normal level.
作者
朱晖
李晨芳
余波
柳晨
肖鸣
ZHU Hui;LI Chenfang;YU Bo;LIU Chen;XIAO Ming(Department of Geratology,General Hospital of Yangtze River Shipping/Wuhan Brain Hospital,Wuhan,Hubei 430010,China;Department of Medical Affairs,General Hospital of Yangtze River Shipping/Wuhan Brain Hospital,Wuhan,Hubei 430010,China;Department of Information,General Hospital of Yangtze River Shipping/Wuhan Brain Hospital,Wuhan,Hubei 430010,China)
出处
《检验医学与临床》
CAS
2021年第1期44-47,共4页
Laboratory Medicine and Clinic
基金
湖北省武汉市新冠肺炎疫情防控应急科研专项项目(EZ20D10)。
