摘要
目的探讨孕早期胎儿颈项透明层厚度(NT)及孕中期血清标志物检测与病理妊娠之间的关系。方法780例孕妇行孕早期NT测量和孕中期血清标志物(游离雌三醇E3、甲胎蛋白AFP、β人绒毛膜促性腺激素β-HCG)检测,分析异常指标与病理妊娠的关系。结果780例孕妇中NT值正常768例,异常12例;正常组胎儿先天畸形发生率低于异常组(P<0.01)。E3降低组胎儿先天畸形、妊娠期糖尿病、妊娠期高血压及胎膜早破发生率高于E3正常组(P<0.01或0.05)。AFP升高组早产、胎儿先天畸形、妊娠期糖尿病、妊娠期高血压及胎膜早破发生率高于AFP正常组或降低组(P<0.01或0.05)。β-HCG升高组妊娠期糖尿病、妊娠期高血压及胎膜早破发生率高于β-HCG正常组或降低组(P<0.01或0.05)。结论孕早期NT检查联合孕中期E3、AFP及β-HCG检测有助于预测病理妊娠。
Objective To investigate the relationship between pathological pregnancy and fetal nuchal translucency(NT)thickness during first trimester and serum markers during second trimester.Methods NT thickness during first trimester and serum markers(free estriol,AFP,andβ-HCG)during second trimester were detected in 780 pregnant women.The relationship between pathological pregnancy and abnormal parameters was analyzed.Results Among 780 pregnant women,768 had normal and 12 abnormal NT.Congenital malformations were more common in normal NT group than in abnormal NT group(P<0.01).Incidence of congenital malformations,gestational diabetes and hypertension,and premature rupture of membrane(PROM)were higher in low estriol group than in normal estriol group(P<0.01 or 0.05).Premature delivery,congenital malformations,gestational diabetes and hypertension,and PROM were more common in high AFP group than in normal or low AFP group(P<0.01 or 0.05).Gestational diabetes and hypertension,and PROM were incremental in highβ-HCG group compared to normal or lowβ-HCG group(P<0.01 or 0.05).Conclusion Combined detection of NT thickness during first trimester and serum levels of free estriol,AFP,andβ-HCG during second trimester can be helpful to predict the pathological pregnancy.
作者
邓姗
李晓玲
沈晓苗
邓清华
DENG Shan;LI Xiao-ling;SHEN Xiao-miao;DENG Qing-hua(Department of Gynecology and Obstetrics,Second Affiliated Hospital,Guangdong Medical University,Zhanjiang 524003,China)
出处
《广东医科大学学报》
2020年第6期741-744,共4页
Journal of Guangdong Medical University
