摘要
目的探讨基于文献报道的复方苦参注射液不良反应与安全用药分析。方法检索1996年1月—2020年2月中国知网(CNKI)、万方数据库(Wanfang data)、维普数据库(VIP)中公开发表的报道复方苦参注射液的药物不良反应(ADR)相关文献,分析涉及ADR病例的一般资料、病史资料、给药方案、ADR相关情况。结果纳入文献共13篇,涉及患者76例。复方苦参注射液导致ADR的发生多集中于40岁以上人群,其中女性(41例)高于男性(35例)。ADR的发生可能与每日给药剂量、溶媒、联合用药等因素有关,首次输注复方苦参注射液30 min内为ADR发生的危险期。ADR临床表现涉及多个系统,其中以胃肠道反应、全身性损害为主。结论临床使用复方苦参注射液时应严格按照说明书给药,关注用药特殊群体,用药过程中,特别是首次输注30 min内,应密切监护,以避免严重ADR的发生。
Objective To explore the analysis of adverse reactions and medication safety of Compound Kushen Injection based on literature reports.Methods From January 1996 to February 2020,the published relevant literatures on adverse drug reaction(ADR)of Compound Kushen Injections were retrieved by computer from CNKI,Wanfang data and VIP.The statistical analysis mainly involved general data,medical history data,dosage regimen and ADR related situation.Results A total of 13 literatures were enrolled,including 76 cases.ADR caused by Compound Kushen Injection mostly occurred in people over 40 years old,and female(41 cases)was higher than male(35 cases).The occurrence of ADR may be related to daily administration dosage,menstruum,drug combination and other factors.The dangerous period of Compound Kushen Injection was 30 minutes after first infusion.The clinical manifestations of ADR could be involved in many systems,among which,gastrointestinal system and systemic damage were the main ones.Conclusion Clinical use of Compound Kushen Injection should be strictly in accordance with the instructions,attention should be paid to special groups.During the use of drugs,especially within 30 min of the first infusion,it is necessary to closely monitor patients to avoid the occurrence of serious ADR.
作者
佃丽萍
韦晓庆
唐帆
张玉柱
钟少文
DIAN Liping;WEI Xiaoqing;TANG Fan;ZHANG Yuzhu;ZHONG Shaowen(The Second Clinical Medical College,Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou510405,China;Department of Mammary Gland,Guangdong Provincial Hospital of Chinese Medicine,Guangdong Province,Guangzhou510000,China)
出处
《中国医药导报》
CAS
2020年第35期140-143,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81904206)。
关键词
复方苦参注射液
药物不良反应
用药安全
文献分析
Compound Kushen Injection
Adverse drug reaction
Medication safety
Literatures analysis
