摘要
目的比较周围型实性肺腺癌和肺鳞癌的18F-FDG PET/CT表现,分析其影像学特征。方法周围型实性肺癌患者98例,其中29例肺鳞癌患者为肺鳞癌组,69例肺腺癌患者为肺腺癌组,均行18 F-FDG PET/CT扫描。比较2组临床资料及18F-FDG PET/CT征象;比较不同年龄、性别、组织病理类型、肿瘤部位、肿瘤最大径、病灶最大标准摄取值(maximum standardized uptake value,SUVmax)。结果肺鳞癌组男性比率(82.8%)高于肺腺癌组(46.4%),女性比率(17.2%)低于肺腺癌组(53.6%)(P<0.05),年龄[(65.21±8.68)岁]、肿瘤最大径[(46.34±21.24)mm]大于肺腺癌组[(59.55±9.58)岁、(32.59±18.33)mm](P<0.05),左、右肺肿瘤比率(31.0%、69.0%)与肺腺癌组(52.2%、47.8%)比较差异均无统计学意义(P>0.05)。肺鳞癌组肺气肿发生率(62.1%)高于肺腺癌组(18.8%)(P<0.05),分叶征、毛刺征、胸膜凹陷征、空泡征、支气管充气征及骨转移发生率(55.2%、37.9%、17.2%、3.4%、0%、13.8%)低于肺腺癌组(82.6%、69.6%、47.8%、23.2%、14.5%、34.8%)(P<0.05);2组血管集束征及支气管截断征发生率比较差异均无统计学意义(P>0.05)。SUVmax在男性(11.41±5.65)大于女性(8.56±4.78),肺鳞癌患者(12.70±5.01)大于肺腺癌患者(9.13±5.32),肿瘤最大径≥3cm者(13.32±5.31)大于肿瘤最大径<3cm者(6.79±3.07)(P<0.05);年龄<60岁与≥60岁、左肺与右肺肿瘤患者SUVmax比较差异均无统计学意义(P>0.05)。结论周围型实性肺腺癌患者18F-FDG PET/CT影像特征以分叶征、毛刺征、胸膜凹陷征、空泡征及支气管充气征多见,易发生骨转移;肺鳞癌男性多见,发病年龄及肿瘤最大径较肺腺癌大,肺气肿发生率高;男性、肺鳞癌、肿瘤最大径≥3cm者SUVmax较大。
Objective To compare the 18F-fluorodeoxyglucose(FDG)positron emission tomography(PET)/CT findings of peripheral solid lung adenocarcinoma and lung squamous cell carcinoma and to analyze their imaging features.Methods In 98patients with peripheral solid lung cancer,there were 29patients with lung squamous cell carcinoma(squamous cell carcinoma group)and 69patients with lung adenocarcinoma(adenocarcinoma group).Both groups received 18F-FDG PET/CT scan.The clinical data and 18F-FDG PET/CT signs were compared between two groups.The maximum standardized uptake value(SUVmax)was compared between patients with different ages,genders,histopathological types,tumor sites and maximum tumor diameters.Results The proportion of male patients was higher in squamous cell carcinoma group(82.8%)than that in adenocarcinoma group(46.4%)(P<0.05),while the proportion of female patients was lower in squamous cell carcinoma group(17.2%)than that in adenocarcinoma group(53.6%)(P<0.05).The patients were older and the diameter of tumor was longer in squamous cell carcinoma group((65.21±8.68)years,(46.34±21.24)mm)than that in adenocarcinoma group((59.55±9.58)years,(32.59±18.33)mm)(P<0.05).There were no significant differences in the proportions of left and right lung tumors between squamous cell carcinoma group(31.0%,69.0%)and adenocarcinoma group(52.2%,47.8%)(P>0.05).The incidence of emphysema was higher in squamous cell carcinoma group(62.1%)than that in adenocarcinoma group(18.8%)(P<0.05),the incidences of foliation,burr,pleural depression,vacuole,air bronchi and bone metastasis were lower in squamous cell carcinoma group(55.2%,37.9%,17.2%,3.4%,0,13.8%)than those in adenocarcinoma group(82.6%,69.6%,47.8%,23.2%,14.5%,34.8%)(P<0.05),while the incidences of vascular cluster and bronchial truncation showed no significant differences between two groups(P>0.05).The SUVmax value was larger in male patients(11.41±5.65)than that in female patients(8.56±4.78)(P<0.05),in squamous cell carcinoma group(12.70±5.01)than that in adenocarcinoma group(9.13±5.32),and in patients with tumor maximum diameter≥3cm(13.32±5.31)than that in patients with tumor maximum diameter<3cm(6.79±3.07)(P<0.05),while it showed no significant differences between patients aged<60years and≥60years as well as between left and right lung tumors(P>0.05).Conclusion Peripheral solid lung adenocarcinoma usually has the 18F-FDG PET/CT features of foliation,burr,pleural depression,vacuole,air bronchi,and bone metastasis.Lung squamous cell carcinoma occurs more often in male patients,with older age and longer tumor diameter compared with lung adenocarcinoma,and the incidence of emphysema is high.The male patients,patients with lung squamous cell carcinoma and patients with tumor maximum diameter of 3cm or longer have larger SUVmax values.
作者
段慧玲
闫瑞芳
王伟
孙凤霞
赵志勇
DUAN Huiling;YAN Ruifang;WANG Wei;SUN Fengxia;ZHAO Zhiyong(Department of Nuclear Medicine,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,China;Department of Magnetic Resonance,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,China)
出处
《中华实用诊断与治疗杂志》
2020年第11期1152-1156,共5页
Journal of Chinese Practical Diagnosis and Therapy
基金
河南省医学科技攻关计划普通项目(201602151)。
关键词
周围型实性肺腺癌
周围型实性肺鳞癌
18F-FDG
PET/CT
最大标准摄取值
peripheral solid lung adenocarcinoma
peripheral solid lung squamous cell carcinoma
18F-fluorodeoxyglucose positron emission tomography/CT
maximum standardized uptake value
