摘要
目的分析心宝丸对冠心病不稳定性心绞痛患者的血液流变学及血脂的影响,为临床治疗提供依据。方法2018年1月—2019年1月,将广东省珠海市人民医院收治的80例冠心病不稳定性心绞痛患者作为研究对象。按随机数表法,分为对照组和观察组,各40例。对照组给予常规治疗,包括长期口服肠溶阿司匹林片及硝酸甘油片,观察组在对照组基础上加用心宝丸。治疗1个月后,分析比较两组患者在治疗效果、血液流变学、血脂水平、不良反应。结果观察组的总有效率(92.5%,37/40)与对照组(80.0%,32/40)相比明显提高,差异具有统计学意义(P <0.05)。治疗前,两组患者的纤维蛋白、血浆黏度、全血黏度无统计学意义(P> 0.05);治疗后,两组患者的上述血液流变学指标均呈下降趋势,且观察组的血液流变学指标均低于对照组,差异具有统计学意义(P <0.05)。治疗前,两组患者的血脂指标水平均无统计学意义(P> 0.05);治疗后,观察组的低密度脂蛋白(LDL-C)、总胆固醇(TC)、甘油三酯(TG)水平与对照组明显降低,而高密度脂蛋白(HDL-C)水平与对照组相比显著提高,差异具有统计学意义(P <0.05)。两组治疗前后凝血功能、血尿常规、肝肾功能等无显著变化,均未见明显不良反应。结论心宝丸对冠心病不稳定性心绞痛患者疗效显著,可明显改善患者血液流变学及血脂水平,值得在临床推广应用。
Objective To analyze the influence of Xinbao Pill on hemorheology and blood lipid in patients with unstable angina pectoris of coronary heart disease so as to provide the basis for clinical treatment. Methods Eighty patients with unstable angina pectoris of coronary heart disease admitted by Zhuhai People’s Hospital were studied from January 2018 to January 2019. According to the method of random number table,the patients were divided into control group and observation group,40 cases in each.The control group was given routine treatment including long-term oral aspirin and nitroglycerin tablets,and the observation group added Xinbao Pill on the basis of the above. The differences of therapeutic effect,hemorheology,blood lipid and side effects of two groups were observed. Results The total effective rate of the observation group( 92. 5%,37/40) was significantly improved compared with that of the control group( 80. 0%,32/40) and the difference was statistically significant( P < 0. 05). Before treatment,fibrin,plasma viscosity and whole blood viscosity of two groups were not significantly significant( P > 0. 05). After treatment,the above hemorheology indexes of the two groups showed a downward trend,and the hemorheology indexes of the observation group were lower than those of the control group. The difference was statistically significantly significant( P < 0. 05). Before treatment,the levels of blood lipid of two groups were not significant( P > 0. 05). After treatment,the levels of LDL-C,TC and TG in the observation group were significantly lower than those in the control group,while the levels of HDL-C were significantly higher than that of the control group( P < 0. 05). There were no significant changes in coagulation function,routine hematuria,liver or kidney function before and after treatment in the two groups. Conclusion Xinbao Pill has a significant effect on the patients with unstable angina pectoris of coronary heart disease,which can improve the hemorheology and blood lipid level of the patients,and is worthy of clinical application.
作者
史礼乐
彭蔚湘
贺献芝
毕怀丽
李军
SHI Lile;PENG Weixiang;HE Xianzhi;BI Huaili;LI Jun(Department of Cardiology,Zhuhai People's Hospital,Zhuhai 519000,Guangdong,China;Nephrology department,Zhuhai People's Hospital,Zhuhai 519000,Guangdong,China)
出处
《辽宁中医杂志》
CAS
2020年第9期110-112,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
冠心病
心宝丸
血液流变学
血脂
心绞痛
疗效
coronary heart disease
Xinbao Pill
hemorheology
blood lipid
angina pectoris
curative effect
