摘要
儿童脓毒症发病率高,是儿童临床危重症引起死亡的主要原因之一,多种炎症途径参与脓毒症的发生发展过程。腱糖蛋白C(TNC)作为一种细胞外基质蛋白,不仅在炎症反应中高度表达,而且可通过Toll样受体4(TLR4)激活下游信号通路,影响炎症因子的释放,共同参与炎症反应的发生发展过程。但目前其在脓毒症中的具体作用机制尚不明确。因此,深入探究TNC在脓毒症中的特异性表达及疾病发生机制研究,可能为儿童脓毒症的早期发现提供生物标志物,以及为脓毒症干预提供新的治疗靶点。
The high incidence of sepsis in children is one of the main causes of death in children with clinical critical illness.Multiple inflammatory pathways are involved in the occurrence and development of sepsis.As an extracellular matrix protein,Tenascin-C(TNC)is not only highly expressed in inflammatory responses,but also can activate downstream signaling pathways through Toll-like receptor 4(TLR4),affect the release of inflammatory factors,and participate in the occurrence of inflammatory responses.However,the specific mechanism of it in sepsis is not clear.Therefore,in-depth exploration of the specific expression of TNC in sepsis and the study of its pathogenesis may provide biomarkers for the early detection of pediatric sepsis and new therapeutic targets for sepsis intervention.
作者
顾洁(综述)
李军(审校)
Gu Jie;Li Jun(Department of Emergency/Critical Medicine,Children′s Hospital of Nanjing Medical University,Nanjing 210008,China)
出处
《国际儿科学杂志》
2020年第10期690-692,共3页
International Journal of Pediatrics
基金
江苏省自然科学基金青年基金项目(BK20170147)
南京市青年人才工程基金(QRX11053)。
