摘要
目的:探讨鼻内镜下Messerklinger手术治疗真菌性鼻-鼻窦炎(FRS)疗效及对患者血清炎症因子的影响。方法:选取2017年6月至2019年6月我院收治的116例FRS患者作为分析对象,按照简单随机分组法将其分为观察组与对照组各58例。对照组患者采用传统柯陆氏手术治疗,观察组患者采用鼻内镜下Messerklinger手术治疗。比较两组患者临床疗效,记录两组患者术后并发症(局部感染、鼻腔黏膜红肿、涕中带血、面部麻木疼痛、牙痛)发生率,观察术前、术后1个月两组患者血清炎性因子[白细胞介素-6(IL-6)、白细胞介素-12(IL-12)、肿瘤坏死因子-α(TNF-α)]、嗜酸性粒细胞阳离子蛋白(ECP)、总免疫球蛋白E(TIgE)水平变化情况。结果:观察组患者临床总有效率(100.00%)高于对照组(93.10%),但差异无统计学意义(P>0.05)。观察组患者术后并发症发生率明显低于对照组(P<0.05)。术后1个月,两组患者血清炎性因子IL-6、IL-12、TNF-α及ECP、TIgE水平较术前均明显降低,且观察组明显低于同期对照组(P<0.05)。结论:鼻内镜下Messerklinger手术治疗FRS疗效显著,能有效减少术后并发症的发生率,减轻患者炎性水平,降低血清ECP、TIgE水平。
Objective:To explore the efficacy of nasal endoscopic Messerklinger surgery on fungal rhinosinusitis(FRS)and its effects on serum level of inflammatory factors of patients.Methods:116 patients with FRS admitted to our hospital from June 2017 to June 2019 were selected as the analysis subjects,and they were divided into observation group and control group with the simple random grouping method,with 58 cases in each group.The patients in control group were treated with traditional Caldwell-Luc surgery,and the patients in observation group were treated with nasal endoscopic Messerklinger surgery.The clinical efficacy of the two groups was compared,and the incidence rates of postoperative complications(local infection,nasal mucosal redness,blood in the nose,facial numbness,toothache)were recorded.The levels of serum inflammatory factors[interleukin-6(IL-6),interleukin-12(IL-12),tumor necrosis factor-α(TNF-α)],eosinophil cationic protein(ECP)and total immunoglobulin E(TIgE)were observed in the two groups before surgery and at 1 month after surgery.Results:The total clinical effective rate in observation group was higher than that in control group(100.00%vs 93.10%)(P>0.05).The incidence rates of postoperative complications in observation group were significantly lower than those in control group(P<0.05).At 1 month after surgery,the levels of serum inflammatory factors IL-6,IL-12,TNF-α,ECP and TIgE in the two groups were significantly lower than those before surgery,and the levels in observation group were significantly lower than those in control group during the same period(P<0.05).Conclusion:Nasal endoscopic Messerklinger surgery has significant efficacy in treating FRS,and it can effectively reduce the incidence rates of postoperative complications,relieve the inflammation level,and reduce the serum ECP and TIgE levels.
作者
王军利
张滟
何珍
WANG Junli;ZHANG Yan(The Second Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710032, China)
出处
《河北医学》
CAS
2020年第11期1761-1765,共5页
Hebei Medicine
基金
国家自然科学基金,(编号:81700902)。
