摘要
目的观察老年胃癌患者实施靶向治疗联合新辅助化疗的临床效果。方法选取2018年2月至2019年8月辽宁省丹东市第一医院收治的58例老年胃癌患者,采用随机数字表法分为两组,每组29例。对照组实施奥沙利铂和卡培他滨治疗,研究组基于对照组治疗方案加行赫赛汀治疗,对照分析两组临床效果。结果研究组临床控制率以及总有效率均高于对照组,差异有统计学意义(P<0.05);治疗后研究组糖类抗原199、糖链抗原724、癌胚抗原、糖链抗原242水平均低于对照组,差异有统计学意义(P<0.05);治疗后两组不良反应发生率对比差异无统计学意义(P>0.05)。结论对于老年胃癌患者来说,靶向治疗联合新辅助化疗可以取得显著效果,显著提高临床控制力及总有效率,降低各项肿瘤标志物水平,且不提高毒副反应发生率。
Objective To analyze the clinical effect of targeted therapy combined with neoadjuvant chemotherapy in elderly patients with gastric cancer.Methods A total of 58 elderly patients with gastric cancer admitted to Dandong First Hospital from February 2018 to August 2019 were divided into two groups using a random number table method,with 29 cases in each group.Control group were treated with oxaliplatin and capecitabine,The study group was treated with Herceptin based on the control group.The clinical effects of the two groups were compared and analyzed.Results The clinical control rate and total effective rate in the study group were higher than those in the control group,difference was statistically significant(P<0.05).The levels of carbohydrate antigen 199,sugar chain antigen 724,carcinoembryonic antigen and sugar chain antigen 242 were lower than those of control group after treatment(P<0.05);There was no significant difference in the incidence of adverse reactions between the two groups after treatment(P>0.05).Conclusion For elderly gastric cancer patients,targeted therapy combined with neoadjuvant chemotherapy can achieve significant results,significantly improve clinical control and total effective rate,reduce the level of various tumor markers,and do not increase the incidence of toxic and side effects.
作者
金京哲
JIN Jingzhe(Dandong First Hospital,Dandong,Liaoning 118000,China)
出处
《大医生》
2020年第13期94-96,共3页
Doctor
关键词
靶向治疗
新辅助化疗
老年人
胃癌
targeted therapy
neoadjuvant chemotherapy
the elderly
cancer of the stomach
