摘要
目的:探讨抗阻力运动对2型糖尿病周围神经病变患者神经症状的改善情况。方法:选取在上海市浦东新区浦南医院内分泌科门诊治疗的2型糖尿病周围神经病变患者100例,随机分为进行抗阻力运动的观察组(n=50)和未进行抗阻力运动的对照组(n=50)。抗阻力运动在bioDensity?抗阻力运动仪器上进行,采用多伦多临床评分系统(Toronto clinical scoring system,TCSS)对糖尿病周围神经病变严重程度分级,以TCSS评分下降水平来评估糖尿病周围神经病变的改善情况。观察组进行为期6个月的抗阻力运动,比较基线与运动3个月、运动6个月患者的体重指数(body mass index,BMI)、腰围、臀围、收缩压、舒张压、空腹血糖(fasting blood glucose,FBG)、空腹胰岛素(fasting insulin, FINS)、糖化血红蛋白(glycosylated hemoglobin, HbAlC)、总胆固醇(total cholesterol, TC)、三酰甘油(glycerin trilaurate, TG)、低密度脂蛋白(low density lipoprotein, LDL)、高密度脂蛋白(high density lipoprotein,HDL)、TCSS评分的变化情况,同时比较观察组基线、3个月、6个月TCSS评分中感觉试验分、神经反射分、神经症状分之间的差异;对照组除不进行抗阻力运动外,其余安排与观察组相同。结果:与对照组比较,3个月时观察组的TCSS评分差异有统计学意义(P<0.05);6个月时观察组的HbA1C和TCSS评分差异有统计学意义(均P<0.05)。与基线比较,观察组3个月、6个月TCSS评分、FBG和HbA1C变化有下降,差异均有统计学意义(均P<0.05);BMI,腰围,臀围,收缩压,舒张压,TC,TG,LDL和HDL的变化差异均无统计学意义(均P>0.05)。观察组TCSS评分中,神经症状评分、感觉试验评分与基线比较均下降,差异均有统计学意义(均P<0.05);神经反射评分与基线比较差异无统计学意义(P>0.05)。对照组中3个月、6个月的TG和TC与基线相比下降,差异有统计学意义(均P<0.05),余指标间差异无统计学意义(均P>0.05)。结论:2型糖尿病周围神经病变患者经抗阻力运动干预后,周围神经病变、血糖得到了一定的改善,可将抗阻力运动在糖尿病患者中进行推广。
Objective: To explore the improvement of neurological symptoms in patients with Type 2 diabetic peripheral neuropathy via resistance exercise.Methods: A total of 100 patients with Type 2 diabetic peripheral neuropathy were selected as the research objects, and they were randomly divided into an observation group who performed resistance exercise(n=50) and a control group who did not performed resistance exercise(n=50). Resistance exercise was performed on the bio Density? resistance exercise instrument. The study graded the severity of diabetic peripheral neuropathy by the Toronto clinical scoring system(TCSS), and the improvement of diabetic peripheral neuropathy(DPN) was evaluated by the decline of the TCSS score. The observation group was treated with resistance exercise for 6 months. The changes of body mass index(BMI), waist circumference, hip circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose(FBG), fasting insulin(FINS), glycosylated hemoglobin(Hb A1 C), total cholesterol(TC), glycerin trilaurate(TG), low density lipoprotein(LDL), high density lipoprotein(HDL), and TCSS score were compared between baseline and 3, 6 months of exercise. At the same time, the differences in sensory test scores, nerve reflex scores, and neurological symptom scores were compared between the baseline, 3 and 6 months, in the observation group. Except for resistance exercise, the other treatments in the control group were the same as those in the observation group.Results: Compared with the control group, there was statistically difference in the TCSS scores in the observation group at 3 months(P<0.05);there were also statistically difference in the Hb A1 C and TCSS scores in the observation group at 6 months(both P<0.05). The changes of TCSS scores, FBG, Hb A1 C in the observation group at 3 months and6 months were significantly lower than those in the baseline, with significant differences(all P<0.05);but there were no significant differences in BMI, waist circumference, hip circumference, systolic blood pressure, diastolic blood pressure and TC, TG, LDL, HDL(all P>0.05). In the TCSS scores, the neurosymptom score, sensory test score were all reduced compared with the baseline, with significant differences(both P<0.05);but there was no significant difference in the neuroreflex score(P>0.05). In the control group, the TG and TC at 3 and 6 months were decreased compared with the baseline, and there was significant difference(both P<0.05), while there was no significant difference in the other indicators(all P>0.05).Conclusion: After the intervention of resistance exercise, the blood glucose and DPN can be improved in a certain extent, and which can be popularized in Type 2 diabetes patients.
作者
杨晓荣
刘连勇
杨玲
李伟萍
张建华
YANG Xiaorong;LIU Lianyong;YANG Ling;LIWeiping;ZHANG Jianhua(Department of Endocrinology,Punan Hospital,Pudong New Area,Shanghai 200125,China)
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2020年第10期1185-1192,共8页
Journal of Central South University ：Medical Science
基金
上海市卫生和计划生育委员会科研项目(20174Y0080)
上海市浦东新区卫生系统领先人才培养计划(PWRl2018-02)
上海市浦东新区卫生系统重点专科培养计划(PWZzk2017-29)。
关键词
2型糖尿病
糖尿病周围神经病变
多伦多临床评分系统
抗阻力运动
Type 2 diabetes mellitus
diabetic peripheral neuropathy
Toronto clinical scoring system
resistance exercise
