摘要
目的探讨奠基方与西药联合治疗多囊卵巢综合征(PCOS)所致不孕的疗效及对子宫内膜分子生物学指标的影响。方法选取2017年2月—2018年8月期间医院收治的多囊卵巢综合征所致不孕患者92例,随机数字表法分成观察组与对照组,每组46例。对照组西医治疗,观察组在此基础上加入奠基方治疗。比较两组疗效及子宫内膜分子生物学指标的变化。结果治疗后,观察组FSH水平高于对照组,T、LH水平低于对照组,差异有统计学意义(P<0.05)。观察组子宫内膜间质及腺体的ER、PR表达均低于对照组,差异有统计学意义(P<0.05)。观察组月经周期改善率、排卵率、卵泡发育率均高于对照组,差异有统计学意义(P<0.05)。观察组子宫内膜厚度厚于对照组,差异有统计学意义(P<0.05)。观察组总有效率91.30%(42/46),高于对照组的69.57%(32/46),差异有统计学意义(P<0.05)。观察组临床妊娠率为47.83%(22/46),高于对照组的17.39%(8/46),差异有统计学意义(P<0.05)。结论奠基方与西药联合治疗多囊卵巢综合征所致不孕患者,可改善临床症状及性激素水平,降低子宫内膜雌激素受体、孕激素受体的表达,提高临床妊娠率。
Objective To investigate the efficacy of the combination of Dianji Prescription and western medicine in the treatment of infertility caused by polycystic ovary syndrome(PCOS)and its influence on the molecular biological parameters of endometrium.Methods A total of 92 infertile patients with polycystic ovary syndrome admitted to hospital from February 2017 to August 2018 were enrolled.The random number table method was used to divide the patients into observation group and control group,with 46 cases in each group.The control group was treated with western medicine,and the observation group was added Dianji Prescription.The effects of the two groups and the changes of endometrial molecular biological indicators were compared.Results After treatment,the level of FSH in the observation group was higher than that in the control group,and the levels of T and LH were lower than those in the control group(P<0.05).The expressions of ER and PR in the endometrial stroma and gland of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).The improvement rate of menstrual cycle,ovulation rate and follicular development rate in the observation group respectively,which were higher than of the control group,and the difference was statistically significant(P<0.05).The thickness of endometrium in the observation group was thicker than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was 91.30%(42/46),which was higher than that of the control group69.57%(32/46),and the difference was statistically significant(P<0.05).The clinical pregnancy rate of the observation group was 47.83%(22/46),which was higher than that of the control group[17.39%(8/46)].The difference was statistically significant(P<0.05).Conclusion The combination of Dianji Prescription and western medicine in the treatment of infertility caused by polycystic ovary syndrome can improve clinical symptoms and sex hormone levels,reduce the expressions of endometrial estrogen receptor and progesterone receptor,and improve the clinical pregnancy rate.
作者
苏会港
孙自红
刘桂阳
SU Huigang;SUN Zihong;LIU Guiyang(Luohe Medical College,Luohe 462000,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第9期85-88,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家科技部科技基础性工作专项基金(2017FY8361071)
河南省医学教育研究项目(Wjlx2018166)。
关键词
奠基方
二甲双胍
多囊卵巢综合征
雌激素受体
孕激素受体
不孕
Dianji Prescription
metformin
polycystic ovary syndrome
estrogen receptor
progesterone receptor
infertility
