摘要
目的探讨小剂量利培酮强化抗抑郁剂治疗双相抑郁发作患者的临床疗效。方法纳入我院2017年5月至2018年2月收治的88例双相抑郁发作患者,根据随机数字表法分为常规组与联合组,各44例。常规组采取常规抗抑郁药物治疗,联合组则采取常规抗抑郁药物加小剂量利培酮强化抗抑郁剂治疗。比较两组患者临床疗效;病情改善时间、住院时间;治疗前后临床疗效总评量表-改善程度(CGI-I)评分、认知功能量表评分、杨氏躁狂量表评分;不良反应发生情况。结果联合组患者总有效率、病情改善时间、住院时间、治疗后CGI-I评分相比常规组更好,P<0.05。联合组患者治疗后认知功能量表评分、杨氏躁狂量表评分、不良反应发生率和常规组比较无明显统计学差异,P>0.05。结论常规抗抑郁药物加小剂量利培酮强化抗抑郁剂治疗双相抑郁发作患者的效果理想,可有效改善患者的病情,提高患者的认知功能,减轻狂躁表现,缩短病情改善时间和住院时间,提高患者的治疗总有效率。
Objective To explore the clinical efficacy of low-dose risperidone intensified antidepressant in the treatment of patients with bipolar depression episode.Methods A total of 88 patients with bipolar depression episode admitted to our hospital from May 2017 to February 2018 were enrolled.They were divided into the conventional group and the combined group by random number table,with 44 cases in each group.The conventional group was treated with conventional antidepressants,and the combined group was treated with conventional antidepressants plus low-dose risperidone intensified antidepressant.To compare the clinical efficacy;the time to improve the condition,the length of hospital stay;the Clinical Global Impressionimprovement of Illness(CGI-I)score,cognitive function scale score,and Young’s Mania Scale score before and after treatment;the occurrence of adverse reactions of the two groups of patients.Results The total effective rate,improvement time,hospitalization time,and CGI-I score of patients in the combined group were better than those in the conventional group,P<0.05.There were no significant differences in the cognitive function scale score,Young's Mania Scale score after treatment,and the incidence of adverse reactions between the combined group and the conventional group,P>0.05.Conclusion Conventional antidepressants plus low-dose risperidone intensified antidepressant are effective in the treatment of patients with bipolar depression episodes.They can effectively improve the patient’s condition,improve the patient’s cognitive function,reduce manic performance,and shorten the improvement time and hospital stay,and improve the overall effective rate of treatment of patient.
作者
刘崇强
张华
LIU Chongqiang;ZHANG Hua(Dalian Seventh People's Hospital,Dalian 116023,China)
出处
《中国医药指南》
2020年第27期61-62,共2页
Guide of China Medicine
关键词
双相抑郁发作
小剂量利培酮
强化抗抑郁剂
临床疗效
认知功能
住院时间
Bipolar depression episode
Low-dose risperidone
Intensified antidepressant
Clinical efficacy
Cognitive function
Length of stay
