摘要
目的探讨妇科恶性肿瘤患者并发静脉血栓栓塞症(VTE)的相关危险因素及预后。方法回顾性分析50例妇科恶性肿瘤并发VTE患者和同期50例无VTE的妇科恶性肿瘤患者的临床资料。收集两组患者的一般情况、血常规指标和凝血功能指标,分析妇科恶性肿瘤患者并发VTE的影响因素及两组患者的生存情况。结果两组患者体质指数、合并糖尿病比例、肿瘤分期、白细胞计数、血小板计数、凝血酶原时间比较,差异均有统计学意义(均P<0.05)。Logistic回归分析结果显示,白细胞计数升高、凝血酶原时间延长是妇科恶性肿瘤患者并发VTE的独立危险因素(P<0.05),并发VTE者的中位生存期、5年总生存率和5年无进展生存率短于或低于无并发VTE者(均P<0.05)。结论白细胞计数升高、凝血酶原时间延长是妇科恶性肿瘤患者并发VTE的独立危险因素,妇科恶性肿瘤患者在手术前后需要进行血常规、凝血功能检查,临床上一旦确诊VTE,应给予早期规范的抗栓治疗,以提高生存率。
Objective To explore the relevant risk factors and prognosis of concomitant venous thromboembolism(VTE)in patients with malignant gynecological tumors.Methods The clinical data of 50 patients with malignant gynecological tumors complicated with VTE and 50 concurrent patients with malignant gynecological tumors but without VTE were analyzed retrospectively.General condition,blood routine indexes,and coagulation function indictors were collected from patients in the two groups,and the influencing factors of patients with malignant gynecological tumors complicated with VTE and the survival of patients in the two groups were analyzed.Results There were statistically significant differences between the two groups in body mass index,proportion of cases complicated with diabetes,tumor stage,WBC count,PLT count,and prothrombin time(all P<0.05).Logistic regression analysis results showed that elevated PLT count and increased prothrombin time were the independent risk factors for developing concomitant VTE in patients with malignant gynecological tumors(P<0.05),those complicated with VTE exhibited shorter median survival time,lower 5-year overall survival rate and 5-year progression-free survival rate as compared with those without concomitant VTE(all P<0.05).Conclusion Elevated PLT count and increased prothrombin time are the independent risk factors for developing concomitant VTE in patients with malignant gynecological tumors.Patients with malignant gynecological tumors need blood routine test and coagulation function examination before and after operation.Once VTE is identified clinically,it is necessary to perform early-stage standardized antithrombotic therapy so as to improve survival rate.
作者
陈钟玉
井水
CHEN Zhong-yu;JING Shui(Department of Gynecology,Suzhou Municipal Hospital of Anhui Province,Suzhou Hospital of Anhui Medical University,Suzhou 234000,China)
出处
《广西医学》
CAS
2020年第18期2385-2388,共4页
Guangxi Medical Journal
关键词
妇科恶性肿瘤
静脉血栓栓塞症
危险因素
预后
Gynecological malignant tumor
Venous thromboembolism
Risk factor
Prognosis
