摘要
A green and efficient synthesis of 3-pyrazolyl indoles was developed by the eye 1 ocondensation reactionof β-ethylthio-β-indolyl-α,β-unsaturated ketones with semi carbazide hydrochloride as hydrazine equivalent in thepresence of 3 equiv. of PEG400(la/PEG mole ratio of 1:3) in reflux water. This procedure did not require toxichydrazine and product purification, eliminating the use of toxic liquid chemicals.
基金
Supported by the National Natural Science Foundation of China(No.20902010)
the Foundation of Science and Technology Research Projects of the 13th Five-year Plan of Jilin Provincial Department of Education,China(No,2016037).
