摘要
目的分析腹腔镜胆囊切除术中荧光显影效果最佳的术前吲哚菁绿注射时机。方法回顾分析2019年1月至11月中国医科大学附属盛京医院行腹腔镜胆囊切除术的102例患者资料,男性42例,女性60例,年龄范围15~87岁,平均年龄49岁。12、7、8、6、6、7、8、10、8、8、8、7、7例患者分别于术前0.5、1、2、3、4、5、6、7、8、9、10、11、12 h静脉注射吲哚菁绿1 ml(2.5 mg/ml),比较术中显影情况、胆囊管与肝脏荧光强度对比值。结果不同时间点注射的患者术中肝脏荧光强度,与0.5 h的患者比较,5、6、7、8、9、10、11、12 h的患者术中肝脏荧光强度更低,差异有统计学意义(均P<0.05)。不同时间点注射的患者术中胆囊、胆囊管、胆总管及肝总管荧光强度比较,差异无统计学意义(均P>0.05)。0.5 h的患者荧光强度对比值低于6、7、8、9、10、11、12 h的患者,差异有统计学意义(均P<0.05)。术前注射时间为7 h,荧光强度对比值可达峰值0.29。结论腹腔镜胆囊切除术前7 h静脉注射2.5 mg吲哚菁绿,术中肝外胆道荧光显影效果最佳。
ObjectiveTo analyze the optimal preoperative timing of indocyanine green administration to do the fluorescence imaging during laparoscopic cholecystectomy.MethodsA total of 102 patients with laparoscopic cholecystectomy from January 2019 to November 2019 were retrospectively analyzed in this study,including 42 male patients and 60 female patients with an average age of 49(15-87)years old.The preoperative timing of indocyanine green(2.5 mg/ml,1 ml)administration was set at 0.5,1,2,3,4,5,6,7,8,9,10,11,and 12 h before surgery,12,7,8,6,6,7,8,10,8,8,8,7,7 patients,respectively.The intraoperative fluorescence imaging and signal contrast were compared.ResultsComparing with 0.5h group,the liver fluorescence intensities in 5,6,7,8,9,10,11 and12 h groups were significantly decreased(all P<0.05).There were no differences in the fluorescence intensities of the gallbladder,gallbladder duct,common bile duct and common liver duct between those groups with different injection timepoints(all P>0.05),and signal contrast was significantly lower in 0.5 h group than patients in 6,7,8,9,10,11 and 12 h groups(all P<0.05).When preoperative timing of indocyanine green administration was 7 h,the fluorescence signal contrast reached the highest values of 0.29.ConclusionsThe optimal preoperative timing of indocyanine green intravenous administration for laparoscopic cholecystectomy under fluorescence navigation was 7 h at dose 2.5 mg.
作者
汪聪
吴硕东
吕超
王潇宁
邱锐
Wang Cong;Wu Shuodong;Lyu Chao;Wang Xiaoning;Qiu Rui(Department of General SurgeryⅡ,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2020年第9期695-698,共4页
Chinese Journal of Hepatobiliary Surgery
关键词
腹腔镜
胆囊切除术
吲哚菁绿
荧光胆道显影
Laparoscopy
Cholecystectomy
Indocyanine green
Fluorescence cholangiography
