摘要
目的研究米非司酮联合羊膜腔注射乳酸依沙吖啶注射液在前置胎盘中期妊娠引产中的应用效果。方法选取2013年11月~2018年9月沈阳市妇婴医院产科收治的74例前置胎盘中期妊娠引产者作为研究对象,按照随机数字表法将其分为对照组与观察组,每组各37例。对照组产妇给予羊膜腔注射乳酸依沙吖啶注射液治疗,观察组产妇给予米非司酮联合羊膜腔注射乳酸依沙吖啶注射液治疗。比较两组的引产结局、引产临床指标及不良反应发生情况。结果观察组产妇的引产时间短于对照组,产后2、24 h出血量少于对照组,引产成功率高于对照组,差异有统计学意义(P<0.05);观察组产妇的清宫术刮出物质量[(24.80±1.50)mg]低于对照组[(54.56±3.05)mg],差异有统计学意义(t=27.431,P=0.000);观察组产妇的宫颈成熟总有效率高于对照组,差异有统计学意义(P<0.05);观察组产妇的胎盘、胎膜残留及粘连总发生率低于对照组,差异有统计学意义(P<0.05);观察组的胃肠道副反应、软产道裂伤发生率与对照组比较,差异无统计学意义(P>0.05)。结论前置胎盘中期妊娠引产者,在排除胎盘植入的前提下,给予米非司酮联合羊膜腔注射乳酸依沙吖啶注射液治疗,宫颈软化明显,从而缩短产程,减少产妇痛苦,降低清宫概率,值得临床应用。
Objective To study the application effect of Mifepristone combined with Ethacridine Lactate Injection amniotic cavity injection on induced labor in the second trimester of placenta previa.Methods A total of 74 patients in Shenyang Maternity Hospital who received induced labors in the second trimester placenta previa from November 2013 to September 2018 were selected as subjects and divided into control group(n=37)and observation group(n=37)according to the random numbers table method.The control group received the amniotic cavity injection Ethacridine Lactate Injection treatment,the obeservation group received the Mifepristone combined with Ethacridine Lactate Injection amniotic cavity injection.The labor outcome,clinical indicators and adverse reactions of induction were compared between the two groups.Results The induction time in the observation group was shorter than that of the control group,the amount of postpartum blood loss in the observation group within 2 and 24 hours after delivery were less than those of the control group,the success rate of labor induction in the observation group was higher than that of the control group,and the differences were statistically significant(P<0.05).The quality of the curettage of the palace in the observation group([24.80±1.50]mg)was lower than that of the control group([54.56±3.05]mg),and the difference was statistically significant(t=27.431,P=0.000).The total effective rate of cervical maturity in the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The total rate of placental fetal membrane residue and adhesion in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).There were no statistically significant differences between the observation group and the control group in the incidence rates of gastrointestinal side effect and soft birth canal damage(P>0.05).Conclusion Mifepristone combined with Ethacridine Lactate Injection amniotic cavity injection is effective in the second trimester induction labor of placenta previa excluding placental implantation,softens the cervix obviously,shortens the labor course,reduces the maternal pain,reduces the palace to clear the probability and is worthy of clinical application.
作者
金良怡
张齐
JIN Liang-yi;ZHANG Qi(Department of Obstetrics,Shenyang Maternity Hospital,Liaoning Province,Shenyang110011,China;Jinzhou Medical University,Liaoning Province,Jinzhou121000,China)
出处
《中国当代医药》
2020年第26期114-117,共4页
China Modern Medicine
关键词
米非司酮
前置胎盘
中期引产
乳酸依沙吖啶注射液
羊膜腔
Mifepristone
Placenta previa
Second trimester induced labor
Ethacridine Lactate Injection
Amniotic cavity
