摘要
BK病毒(BK virus,BKV)在人群中普遍易感,其感染是造成肾移植受者移植器官丧失功能的重要因素。为了深入了解BK病毒在2019年广州地区的流行情况,本研究对广州地区的164例肾移植受者的血液和尿液样本的感染情况进行了监测,检测结果表明尿液检出率为32.5%(66/203),血液样本检出率为4.3%(8/185)。对其中20株BK病毒VP1区系统进化分析的结果表明,其中10株属于I型,10株属于IV型,并初步分析了不同临床类型病例的基因型分布的特点。本研究提示至少有I、IV两个基因型的BK病毒在全国范围共流行,其中广州地区两个基因型的流行情况相当,以上数据有助于深入了解我国BK病毒分子流行病学研究,为分子检测试剂以及本土疫苗的研发提供基础依据。
BK virus(BKV) is generally susceptible in the population worldwide,and its infection is an important factor leading to organ failure in renal transplant recipients. In order to understand the prevalence of BK virus,the BKV infection of blood and urine samples of 164 renal transplant recipients in Guangzhou,were monitored. The results showed that the positive rate of urine samples was 32.5%(66/203). The positive rate of blood samples was 4.3%(8/185). Phylogenetic analysis of the VP1 region of BK virus showed that 10 strains belonged to genotype I and 10 strains belonged to genotype IV,and the genotypic distribution characteristics of different clinical types were analyzed. This study suggests that at least two genotypes of BK virus,I and IV,are prevalent in China,and the prevalence of the two genotypes in Guangzhou,is similar. The above data are helpful to further understand the molecular epidemiology of BK virus in China. It provides the basis for the research and development of molecular detection reagents and native vaccines.
作者
李磊
邓家成
范雪娇
何文茵
梁君瑜
蔡瑞明
LI Lei;DENG Jiacheng;FAN Xuejiao;HE Wenyin;LIANG Junyu;CAI Ruiming(The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China;KingMed School of Laboratory Medicine,Guangzhou Medical University,Guangzhuu 510182,China)
出处
《病毒学报》
CAS
CSCD
北大核心
2020年第5期871-878,共8页
Chinese Journal of Virology
基金
广东省医学科学技术研究基金项目(项目号:A2018488)
广州市卫生和计划生育科技项目(项目号:20181A011082)
广州医科大学附属第三医院自然科学青年项目(项目号:2018Q13)。
关键词
BK病毒
基因型
肾移植
BK virus
Genotype
Renal transplantation
