摘要
目的观察分析来氟米特联合拉米夫定治疗肾病综合征合并乙肝病毒感染患者的效果。方法选取2017年1月至2018年10月中国人民解放军陆军第八十集团军医院收治的39例肾病综合征合并乙肝病毒感染患者,按照随机数字表法分为两组,其中观察组20例,对照组19例。对照组患者采取甲基强的松龙+来氟米特治疗,观察组则在对照组患者的基础上加入拉米夫定治疗。比较两组患者在临床疗效、治疗前后乙肝病毒的脱氧核糖核酸(HBV-DNA)滴度以及血生化指标的变化。结果观察组患者的临床疗效明显高于对照组(P<0.05)。两组患者治疗前的HBV-DNA滴度比较,差异无统计学意义(P>0.05);两组治疗后的HBV-DNA滴度优于治疗前,观察组治疗后的HBV-DNA滴度改善幅度明显高于对照组(P<0.05)。两组治疗前血清白蛋白、谷丙转氨酶、尿蛋白、血肌酐、谷草转氨酶的比较差异无统计学意义(P>0.05);两组患者治疗后的血清白蛋白、谷丙转氨酶、尿蛋白、血肌酐、谷草转氨酶优于对照组(P<0.05);观察组治疗后血清白蛋白、谷丙转氨酶、尿蛋白、血肌酐、谷草转氨酶均明显优于对照组(P<0.05)。结论肾病综合征合并乙肝病毒感染患者来氟米特联合拉米夫定治疗的效果显著,具有较高安全性。
Objective To observe and analyze the effect of leflunomide combined with lamivudine in the treatment of patients with nephrotic syndrome and hepatitis B virus infection.Methods A total of 39 patients with nephrotic syndrome and hepatitis B virus infection who were admitted to the 80th Army Hospital of the Chinese People’s Liberation Army from January 2017 to October 2018 were divided into two groups according to the random number table method,including 20 cases in the observation group and control group 19 cases.The control group was treated with methylprednisolone+leflunomide.In the observation group,lamivudine was added to the control group.The clinical efficacy,HBV-DNA titer and changes of blood biochemical indexes before and after treatment were compared between the two groups.Results The clinical efficacy of the observation group was significantly higher than that of the control group(P<0.05).The comparison of HBV-DNA titers before treatment between the two groups was not statistically significant(P>0.05);the HBV-DNA titers after treatment in the two groups were better than those before treatment.The improvement range of HBV-DNA titers in the observation group after treatment It was significantly higher than the control group(P<0.05).There was no significant difference in serum albumin,alanine aminotransferase,urine protein,serum creatinine,and aspartate aminotransferase between the two groups before treatment(P>0.05);the serum albumin,alanine aminotransferase,urine protein,and blood levels of the two groups after treatment creatinine and aspartate aminotransferase were better than the control group(P<0.05);serum albumin,alanine aminotransferase,urine protein,serum creatinine,and aspartate aminotransferase in the observation group were significantly better than the control group after treatment(P<0.05).Conclusion Leflunomide combined with lamivudine in patients with nephrotic syndrome combined with hepatitis B virus infection has a significant effect and high safety.
作者
李辉
马爱华
潘丽丽
LI Hui;MA Aihua;PAN Lili(The 80th Army Hospital of the Chinese People's Liberation Army,Weifang,Shandong 261021,China)
出处
《大医生》
2020年第7期121-123,共3页
Doctor
关键词
肾病综合征
乙肝病毒感染
来氟米特
拉米夫定
nephrotic syndrome
hepatitis B virus infection
leflunomide
lamivudine
