摘要
糖尿病肾脏疾病(diabetic kidney disease,DKD)是糖尿病主要并发症之一,因缺乏有效治疗药物,该病预后不良,可进展至终末期肾病,为个人和社会带来沉重负担。近年来,从治疗机制到具体药物的各种研究不断涌现,尤其是多项大型临床试验的结果,为治疗DKD带来了希望。本文参考近年来最新研究,对新型降糖药(钠⁃糖共转运体2抑制剂、胰高血糖素样肽1受体激动剂、二肽基肽酶Ⅳ抑制剂)、蛋白激酶C抑制剂、抗糖基化终末产物、醛固酮受体拮抗剂等药物,以及抗氧化、抗炎症和抗纤维化等DKD治疗策略的进展作一综述,为临床规范治疗提供依据。
Diabetic kidney disease(DKD)is one of the main complications of diabetes mellitus because there is no effective treatment,many DKD progressed to ESRD,bring heavy burden for in dividuals and society.There has been an explosion of studies on the treatment regarding mechanisms and drugs in recent years.We reviewed latest researches on sodium⁃glucose cotransporter⁃2 inhibitor,glucagon⁃like peptide⁃1 receptor agonist,dipeptidyl peptidase⁃4 inhibitor,protein kinase⁃C inhibitor,advanced glycation end products inhibitor,mineralocorticoid receptor antagonist,as well as up⁃to⁃date therapies inhibiting oxidative stress,inflammation and fibrosis so that clinicians could have a reference on the treatment of DKD.
作者
施雯(综述)
张晓良(审校)
SHI Wen;ZHANG Xiaoliang(Institute of Nephrology,Zhong Da Hospital,Southeast University School of Medicine,Nanjing 210009,China)
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
北大核心
2020年第4期375-380,共6页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
国家自然科学基金(81570612)
国家自然科学基金(81870497)。
