摘要
目的:探讨重组人干扰素α1b雾化联合盐酸氨溴索治疗慢性支气管炎急性发作患者的临床疗效。方法:选取2018年1月-2019年12月笔者所在医院慢性支气管炎急性发作患者135例,按随机数字表法分研究组(n=68)、对照组(n=67)。对照组采用盐酸氨溴索雾化吸入治疗,研究组采用重组人干扰素α1b联合盐酸氨溴索雾化吸入治疗。比较两组总有效率、临床症状(气喘、哮鸣音、咳嗽咳痰)缓解时间、治疗前后血清炎性因子[干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)]水平。结果:研究组总有效率为94.12%(64/68),高于对照组的74.63%(50/67),差异有统计学意义(P<0.05);研究组气喘、哮鸣音、咳嗽咳痰缓解时间均早于对照组(P<0.05);治疗后研究组血清IFN-γ水平高于对照组,IL-4水平低于对照组(P<0.05)。结论:重组人干扰素α1b雾化联合盐酸氨溴索治疗慢性支气管炎急性发作患者临床疗效显著,可促进症状缓解,改善机体炎症状态。
Objective:To investigate the clinical effect of Nebulized Recombinant Human Interferon Alpha 1b combined with Ambroxol Hydrochloride in the treatment of acute attack of chronic bronchitis.Method:A total of 135 patients with acute attack of chronic bronchitis in our hospital from January 2018 to December 2019 were selected and divided into study group(n=68)and control group(n=67)according to the random number table.The control group was treated with Ambroxol Hydrochloride atomization inhalation,while the study group was treated with Recombinant Human Interferon Alpha 1b combined with Ambroxol Hydrochloride atomization inhalation.The total effective rate,remission time of clinical symptoms(asthma,wheezing,cough and sputum),and serum levels of inflammatory factors[interferon-γ(IFN-γ),interleukin-4(IL-4)]before and after treatment were compared between the two groups.Result:The total effective rate in the study group was 94.12%(64/68),higher than 74.63%(50/67)in the control group(P<0.05).The remission time of asthma,wheezing and cough and sputum in the study group was shorter than those in the control group(P<0.05).After treatment,serum IFN-γlevel in the study group was higher than that in the control group,and IL-4 level was lower than that in the control group(P<0.05).Conclusion:Atomized recombinant human interferon alpha 1b combined with ambroxol hydrochloride in the treatment of acute attack of chronic bronchitis has a significant clinical effect,which can promote the relief of symptoms and improve the inflammatory state of the body.
作者
陈永华
李显良
高鹏
CHEN Yonghua;LI Xianliang;GAO Peng(The Second People’s Hospital of Macheng,Macheng 438300,China;不详)
出处
《中外医学研究》
2020年第24期50-52,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
慢性支气管炎急性发作
重组人干扰素Α1B
盐酸氨溴索
Acute attack of chronic bronchitis
Recombinant Human Interferon alpha 1b
Ambroxol hydrochloride
