摘要
目的:观察"调理脾胃"针法治疗糖尿病胃轻瘫(DGP)的疗效,并探讨其可能的机制。方法:将128例DGP患者随机分为观察组(64例,脱落4例)和对照组(64例,脱落4例)。在西药控制血糖的基础上,观察组采用"调理脾胃"针法,穴取中脘、足三里、阴陵泉、血海、三阴交、地机等,每日1次;对照组口服枸橼酸莫沙必利分散片5 mg,每日3次。两组均每周治疗6 d,共治疗4周。比较两组患者治疗前后胃轻瘫症状评分、血清跨膜蛋白16A(ANO1)含量,并评定临床疗效及安全性。结果:治疗后,两组患者胃轻瘫症状评分各分项(嗳气、腹胀、食欲不振、恶心呕吐、上腹痛、大便异常)评分及总分均降低(P<0.05),观察组嗳气、腹胀、食欲不振、恶心呕吐评分及总分低于对照组(P<0.05)。治疗后,两组患者血清ANO1的含量均降低(P<0.05),且观察组低于对照组(P<0.05)。观察组总有效率为86.7%(52/60),高于对照组的70.0%(42/60,P<0.05)。观察组出现5例皮下血肿,经冷敷处理得以改善,无需其他特殊处理。结论:"调理脾胃"针法与枸橼酸莫沙必利分散片相比,改善糖尿病胃轻瘫患者症状的效果更佳,其机制可能与减轻Cajal间质细胞(ICC)损伤有关。
Objective To observe the therapeutic effect of Tiaoli Piwei needling technique(acupuncture for regulating spleen and stomach)on diabetic gastroparesis(DGP),and to explore its possible mechanism.Methods A total of 128 patients with DGP were randomized into an observation group(64 cases,4 cases dropped off)and a control group(64 cases,4 cases dropped off).On the basis of intervention on controlling blood glucose by western medication,Tiaoli Piwei needling technique was adopted at Zhongwan(CV 12),Zusanli(ST 36),Yinlingquan(SP 9),Xuehai(SP 10),Sanyinjiao(SP 6),Diji(SP 8),etc.in the observation group,once a day.Mosapride citrate dispersible tablet 5 mg was given orally 3 times a day in the control group.The treatment was given 6 times a week in the both groups,and totally 4-week treatment was required.Before and after treatment,the DGP symptom score,serum content of transmembrane protein 16 A(ANO1)were observed,and the clinical therapeutic effect and the safety were evaluated in the both groups.Results After treatment,the each subitem score(belching,abdominal distension,inappetence,nausea and vomiting,epigastric pain,abnormal defecation)and the total score of DGP symptom were decreased in both groups(P<0.05),the subitem scores of belching,abdominal distension,inappetence,nausea and vomiting and the total score in the observation group were lower than those in the control group(P<0.05).After treatment,the serum contents of transmembrane protein 16 A were reduced in both groups(P<0.05),and that in the observation group was lower than the control group(P<0.05).The total effective rate was 86.7%(52/60)in the observation group,which was superior to 70.0%(42/60)in the control group(P<0.05).Subcutaneous hematoma occurred in 5 cases in the observation group,which was improved after cold compress without other particular intervention.Conclusion The therapeutic effect of Tiaoli Piwei needling technique on improving symptoms in patients with diabetic gastroparesis is superior to mosapride citrate dispersible tablet,its mechanism may be related to alleviating the damage of interstitial cells of Cajal(ICC).
作者
宋妍瑾
王栩
李鑫举
张智龙
SONG Yan-jin;WANG Xu;LI Xin-ju;ZHANG Zhi-long(Graduate School of Tianjin University of TCM,Tianjin 300193,China;Department of Acupuncture and Moxibustion,Affiliated Hospital of Tianjin Academy of TCM,Tianjin 300120)
出处
《中国针灸》
CAS
CSCD
北大核心
2020年第8期811-815,共5页
Chinese Acupuncture & Moxibustion
基金
国家自然科学基金资助项目:81373784。
关键词
糖尿病胃轻瘫
针刺
“调理脾胃”针法
枸椽酸莫沙必利分散片
跨膜蛋白16A
随机对照试验
diabetic gastroparesis
acupuncture
Tiaoli Piwei needling technique
mosapride citrate dispersible tablet
transmembrane protein 16A
randomized controlled trial(RCT)
