摘要
目的:研究蓝光照射联合综合治疗对新生儿溶血症所致高胆红素血症患儿血清指标的调节作用。方法:90例新生儿溶血症所致高胆红素血症患儿,简单随机分为两组,干预组接受蓝光照射联合综合药物治疗;对照组接受综合药物治疗。治疗前后分别检测血清中TBIL、MDA、神经功能相关分子、肝肾功能相关分子的含量。结果:联合组患儿仅1例患儿治疗无效,总有效率为97.78%(44/45),显著高于对照组(χ^2=10.88,P=0.001)。两组患儿的血清TBIL含量治疗前无差异;治疗后,联合组患儿的血清TBIL含量明显低于药物组(P<0.05)。患者在进行治疗前,其α-谷胱甘肽-S转移酶以及血清谷氨酸脱氢酶的含量没有显著性的差异;治疗后联合组患儿的血清谷氨酸脱氢酶含量低于药物组(P<0.05)。对比两组患儿血清MDA,治疗前无差异,治疗后联合组患儿的血清MDA含量低于药物组(P<0.05)。两组患儿的血清NSE含量治疗前无差异;治疗后联合组患儿的血清NSE含量低于药物组(P<0.05)。结论:在对于高胆红素血症患儿治疗的过程中,蓝光照射联合综合治疗有着较好的效果,不仅能够使得胆红素含量有效降低,同时也能够保护患儿神经功能,有着极其重要的临床应用价值。
Objective:To study the regulatory effect of blue light irradiation combined with comprehensive treatment on serum indexes of hyperbilirubinemia caused by hemolytic disease of the newborn.Methods:90 children with hyperbilirubinemia caused by hemolytic disease of the newborn were randomly divided into two groups:the intervention group was treated with blue light irradiation combined with comprehensive drug treatment;the control group was treated with comprehensive drug treatment.The levels of TBIL,MDA,neurofunctional molecules,liver and kidney functional molecules were detected before and after treatment.Results:With one case in the intervention group being ineffective,the total effective rate was 97.78%(44/45),significantly higher than that in the control group(χ^2=10.88,P=0.001).There was no difference in serum TBIL content between the two groups before treatment;After treatment,the serum TBIL content of the intervention group was significantly lower than that of the contro group(P<0.05).Before the treatment,there was no significant difference in the content ofα-glutathione-s transferase and serum glutamate dehydrogenase between the two groups;after the treatment,the content of serum glutamate dehydrogenase in the intervention group was lower than that in the control group(P<0.05).There was no difference in serum MDA between the two groups before treatment,while,After treatment,the serum MDA content of the combined group decreased significantly,which was lower than that of the drug group(P<0.05).There was no difference in serum NSE content between the two groups before treatment;after treatment,the serum NSE content of the intervention group was significantly lower than that of the control group(P<0.05).Conclusion:In the treatment of hyperbilirubinemia,the combination of blue light irradiation and comprehensive treatment has a good effect.It not only effectively reduces the bilirubin content,but also protects children's nerve function,which has an extremely important clinical application value.
作者
李克泉
刘美
薛见珍
LI Kequan(Jiaozhou Central Hospital of Qingdao, Shandong Qingdao 266300, China)
出处
《河北医学》
CAS
2020年第8期1273-1277,共5页
Hebei Medicine
基金
山东省青岛市卫生科技计划项目,(编号:2015-WJZD073)。
关键词
新生儿溶血症
高胆红素血症
蓝光照射
总胆红素
神经功能
Hemolysis of newborn
Hyperbilirubinemia
Blue light irradiation
Total bilirubin
Nerve function
