摘要
胰腺癌是全球最具侵袭性和致死性的恶性肿瘤之一。在胰腺癌发生发展的过程中,自噬在其中扮演着非常重要的角色。但是自噬在胰腺癌病理生物学以及治疗的作用是复杂的,在不同的细胞环境中表现出不同的功能。这使得自噬在胰腺癌的发生、发展中,既有保护作用,又有抑制作用。本文就自噬在胰腺癌中发生过程、作用机理、治疗策略进行相关的阐述。
Pancreatic cancer is one of the most aggressive and fatal malignant tumors in the world.Autophagy plays a very important role in the development of pancreatic cancer.However,the role of autophagy in the pathophysiology and treatment of pancreatic cancer is complex,showing different functions in different cellular environments.This makes autophagy have both protective and inhibitory effects in the occurrence and development of pancreatic cancer.In this paper,the pathogenesis,mechanism and treatment strategies of autophagy in pancreatic cancer were reviewed.
作者
张欢宇(综述)
黄用豪(审校)
ZHANG Huan-yu;HUANG Yong-hao(Hainan Provincial Key Laboratory of Tropical Medicine,Hainan Medical College,Haikou 571199,Hainan,CHINA)
出处
《海南医学》
CAS
2020年第15期1992-1996,共5页
Hainan Medical Journal
基金
国家自然科学基金(编号:81860429)。
关键词
肿瘤
胰腺癌
自噬
自噬性细胞死亡
保护性自噬
Tumor
Pancreatic cancer
Autophagy
Autophagic cell death
Protective autophagy
